Anna Weinzinger

Publications

Publications per year 2007 2008 2010 2011 2012 2013 2014 2017 2019 2020 2022 2024

• 59 Article
• 4 Meeting abstract/Conference paper
• 2 Review
• 1 Special Issue

Publications per year

Publications per year

Search results

• 2024

  In silico models of the macromolecular NaV1.5-KIR2.1 complex

  Weinzinger, A., Feb 2024, In: Frontiers in Physiology. 15, 1362964.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2023

  Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate

  Plessl, E-M., Wu, W., Sanguinetti, M. C. & Weinzinger, A., 2023, In: Frontiers in Molecular Biosciences. 10, 1137368.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Subunit gating resulting from individual protonation events in Kir2 channels

  Maksaev, G., Bründl-Jirout, M., Stary-Weinzinger, A., Zangerl-Plessl, E-M., Lee, S-J. & Nichols, C. G., 28 Jul 2023, In: Nature Communications. 14, 1, p. 4538 4538.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2022

  A selectivity filter mutation provides insights into gating regulation of a K⁺ channel

  Friesacher, T., Reddy, H. P., Bernsteiner, H., Carlo Combista, J., Shalomov, B., Bera, A. K., Zangerl-Plessl, E. M., Dascal, N. & Stary-Weinzinger, A., 11 Apr 2022, In: Communications Biology. 5, 1, 13 p., 345.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Development of I_KATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant K_IR6.2 Based Channels for Treating DEND Syndrome.

  Weinzinger, A., 14 Jan 2022, In: Frontiers in Pharmacology. 12, 15 p., 814066.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels

  Hackl, B., Lukacs, P., Ebner, J., Pesti, K., Haechl, N., Földi, M. C., Lilliu, E., Schicker, K., Kubista, H., Stary-Weinzinger, A., Hilber, K., Mike, A., Todt, H. & Koenig, X., 2 May 2022, In: Frontiers in Pharmacology. 13, 15 p., 809802.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• β subunits of GABA_A receptors form proton-gated chloride channels: Insights into the molecular basis

  Garifulina, A., Friesacher, T., Stadler, M., Zangerl-Plessl, E. M., Ernst, M., Stary-Weinzinger, A., Willam, A. & Hering, S., 3 Aug 2022, In: Communications Biology. 5, 1, 10 p., 784.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2021

  Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels

  Bründl, M., Pellikan, S. & Weinzinger, A., 10 Aug 2021, In: Frontiers in Molecular Biosciences. 8, 11 p., 711975.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2020

  Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

  Plessl, E-M., Lee, S. J., Maksaev, G., Bernsteiner, H., Ren, F., Yuan, P., Weinzinger, A. & Nichols, C. G., Jan 2020, In: Journal of General Physiology. 152, 1, 16 p., e201912422.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K + Channel

  Chen, X., Bründl, M., Friesacher, T. & Weinzinger, A., 15 May 2020, In: Frontiers in Pharmacology. 11, 9 p., 721.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1

  Qile, M., Golden, T. D., Houtman, M. J. C., Weinzinger, A., van der Heyden, M. A. G., van Ham, W., Romunde, F. L., Fransen, D., IJzerman, A. P., January, C. T., Heitman, L. H. & Delisle, B. P., Jun 2020, In: Molecular Pharmacology. 97, 6, p. 355-364 10 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574

  Plessl, E-M., Berger, M., Drescher, M., Chen, Y., Wu, W., Maulide, N., Sanguinetti, M. C. & Weinzinger, A., Jan 2020, In: Journal of Chemical Information and Modeling. 60, 1, p. 360-371 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2019

  A structural model of the human serotonin transporter in an outward-occluded state

  Hellsberg, E., Ecker, G., Weinzinger, A. & Forrest, L. R., 28 Jun 2019, In: PLoS ONE. 14, 6, 25 p., e0217377.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Computational identification of novel Kir6 channel inhibitors

  Chen, X., Garon, A., Wieder, M., Houtman, M. J. C., Zangerl-Plessl, E. M., Langer, T., Van Der Heyden, M. A. G. & Stary-Weinzinger, A., May 2019, In: Frontiers in Pharmacology. 10, 13 p., 549.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Conduction through a narrow inward-rectifier K+ channel pore.

  Bernsteiner, H., Plessl, E-M., Chen, X. & Weinzinger, A., Sep 2019, In: Journal of General Physiology.

  Publications: Contribution to journal › Article › Peer Reviewed

• Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents

  Weinzinger, A., Aug 2019, In: Journal of Cellular and Molecular Medicine. 23, 8, p. 4962-4969 8 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go (Eag) channel superfamily member Kv 12.1.

  Weinzinger, A., Aug 2019, In: British Journal of Pharmacology. 176, 15, p. 2708-2723 16 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• LUF7244, an allosteric modulator/activator of K(v)11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

  Qile, M., Beekman, H. D. M., Sprenkeler, D. J., Houtman, M. J. C., van Ham, W., Weinzinger, A., Beyl, S., Hering, S., van den Berg, D-J., de Lange, E. C. M., Heitman, L. H., IJzerman, A. P., Vos, M. A. & van der Heyden, M., 8 Oct 2019, In: British Journal of Pharmacology. 176, 19, p. 3871-3885 15 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2018

  Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are I-Kr blockers with proarrhythmic effects in vitro and in vivo

  Baburin, I., Varkevisser, R., Schramm, A., Saxena, P., Beyl, S., Szkokan, P., Linder, T., Stary-Weinzinger, A., van der Heyden, M. A. G., Houtman, M., Takanari, H., Jonsson, M., Beekman, J. H. D., Hamburger, M., Vos, M. A. & Hering, S., May 2018, In: Pharmacological Research. 131, p. 150-163 14 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures

  Cervenka, R., Lukacs, P., Gawali, V. S., Ke, S., Koenig, X., Rubi, L., Zarrabi, T., Hilber, K., Sandtner, W., Stary-Weinzinger, A. & Todt, H., 12 Jan 2018, In: Scientific Reports. 8, 1, 15 p., 631.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole

  Gualdani, R., Cavalluzzi, M. M., Tadini-Buoninsegni, F., Convertino, M., Gailly, P., Stary-Weinzinger, A. & Lentini, G., 2018, In: Cellular Physiology and Biochemistry. 45, 6, p. 2233-2245 13 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2017

  Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel

  Cooper, P. E., McClenaghan, C., Chen, X., Stary-Weinzinger, A. & Nichols, C. G., 20 Oct 2017, In: Journal of Biological Chemistry. 292, 42, p. 17387-17398 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations

  Bernsteiner, H., Bründl, M. & Stary-Weinzinger, A., 26 Feb 2017, In: Biochemical and Biophysical Research Communications. 484, 1, p. 107-112 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3

  Gardner, A., Wu, W., Thomson, S., Zangerl-Plessl, E-M., Stary-Weinzinger, A. & Sanguinetti, M. C., Oct 2017, In: Molecular Pharmacology. 92, 4, p. 437-450 14 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

  Ji, Y., Veldhuis, M. G., Zandvoort, J., Romunde, F. L., Houtman, M. J. C., Duran, K., van Haaften, G., Zangerl-Plessl, E-M., Takanari, H., Stary-Weinzinger, A. & van der Heyden, M. A. G., 15 Jul 2017, In: Journal of Biomedical Science. 24, 1, p. 44 10 p., 44.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2016

  Drug trapping in hERG K⁺ channels: (Not) a matter of drug size?

  Linder, T., Bernsteiner, H., Saxena, P., Bauer, F., Erker, T., Timin, E., Hering, S. & Stary-Weinzinger, A., 1 Mar 2016, In: MedChemComm. 7, 3, p. 512-518 7 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• New potential binding determinant for hERG channel inhibitors

  Saxena, P., Zangerl-Plessl, E-M., Linder, T., Windisch, A., Hohaus, A., Timin, E., Hering, S. & Stary-Weinzinger, A., 12 Apr 2016, In: Scientific Reports. 6, 10 p., 24182.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids

  Lee, S. J., Ren, F., Zangerl-Plessl, E-M., Heyman, S., Stary-Weinzinger, A., Yuan, P. & Nichols, C. G., 2016, In: Journal of General Physiology. 148, 3, p. 227-237 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2015

  Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels

  Linder, T., Wang, S., Plessl, E-M., Nichols, C. G. & Weinzinger, A., 20 Mar 2015, In: Journal of Chemical Information and Modeling. 55, 4, p. 814–822 9 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2014

  Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations.

  Ke, S., Timin, E. & Weinzinger, A., 2014, In: PLoS Computational Biology. 10, 7, e1003746.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

  • Conformational Change 100%
  • Molecular Dynamics 100%
  • Selectivity 100%
  • Conductance 66%
  • Conformation 66%

• Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.

  Lukacs, P., Gawali, V., Cervenka, R., Ke, S., Rubi, L., Zarrabi, T., Hilber, K., Weinzinger, A. & Todt, H., 2014, In: Journal of Biological Chemistry. 289, 31, p. 21770-21781 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

  • Electric Potential 100%
  • Mutation 100%
  • Crystal Structure 75%
  • Potassium Channel 25%
  • Membrane 25%

• Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

  Houtman, M. J. C., Korte, M., Yi, Y., Vos, M. A., van der Heyden, M. A. G. & Weinzinger, A., 3 Oct 2014, In: Biochemical and Biophysical Research Communications. 452, 4, p. 992-997 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  • Kir2.1 100%
  • Snake 100%
  • Inward-Rectifier Potassium Ion Channel 100%
  • Ion Channel 66%
  • Turtle 66%

• Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine

  Thurner, P., Stary-Weinzinger, A., Gafar, H., Gawali, V. S., Kudlacek, O., Zezula, J., Hilber, K., Boehm, S., Sandtner, W. & Koenig, X., Feb 2014, In: Journal of Pharmacology and Experimental Therapeutics. 348, 2, p. 346-358 13 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Structural Insights into Trapping and Dissociation of Small Molecules in K+ Channels

  Linder, T., Saxena, P., Timin, E., Hering, S. & Weinzinger, A., Nov 2014, In: Journal of Chemical Information and Modeling. 54, 11, p. 3218-3228 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2013

  Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue

  Takanari, H., Nalos, L., Stary-Weinzinger, A., de Git, K. C. G., Varkevisser, R., Linder, T., Houtman, M. J. C., Peschar, M., de Boer, T. P., Tidwell, R. R., Rook, M. B., Vos, M. A. & van der Heyden, M. A. G., 1 Jul 2013, In: Cardiovascular Research. 99, 1, p. 203-214 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels

  Garg, V., Stary-Weinzinger, A. & Sanguinetti, M. C., Apr 2013, In: Molecular Pharmacology. 83, 4, p. 805-813 9 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs

  van der Heyden, M. A. G., Stary-Weinzinger, A. & Sanchez-Chapula, J. A., Sep 2013, In: Current molecular medicine. 13, 8, p. 1284-98 15 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Probing the energy landscape of activation gating of the bacterial potassium channel KcsA

  Linder, T., de Groot, B. L. & Stary-Weinzinger, A., 2013, In: PLoS Computational Biology. 9, 5, e1003058.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue

  Varkevisser, R., Houtman, M. J. C., Linder, T., de Git, K. C. G., Beekman, H. D. M., Tidwell, R. R., Ijzerman, A. P., Stary-Weinzinger, A., Vos, M. A. & van der Heyden, M. A. G., Jul 2013, In: British Journal of Pharmacology. 169, 6, p. 1322-1334 13 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2012

  Distinct interactions of Na(+) and Ca(2+) ions with the selectivity filter of the bacterial sodium channel Na(V)Ab.

  Ke, S., Zangerl, E-M. & Weinzinger, A., 2012, In: Biochemical and Biophysical Research Communications. 430, 4, p. 1272-1276 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model

  Beyl, S., Depil, K., Hohaus, A., Weinzinger, A., Linder, T., Timin, E. & Hering, S., Oct 2012, In: Pflügers Archiv: European Journal of Physiology. 464, 4, p. 391-401 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Surprises from an Unusual CLC Homolog

  Phillips, S., Brammer, A. E., Rodriguez, L., Lim, H-H., Weinzinger, A. & Matulef, K., 2012, In: Biophysical Journal. 103, 9, p. 44-46 3 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2011

  Computer simulations of structure-activity relationships for HERG channel blockers.

  Boukharta, L., Keranen, H., Weinzinger, A., Wallin, G., De Groot, B. & Aqvist, J., 2011, In: Biochemistry. 50, 27, p. 6146-6156 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• In silico Analysis of Conformational Changes Induced by Mutation of Aromatic Binding Residues: Consequences for Drug Binding in the hERG K+ Channel.

  Knape, K., Linder, T., Wolschann, K. P., Beyer, A. & Weinzinger, A., 2011, In: PLoS ONE. 6, 12

  Publications: Contribution to journal › Article › Peer Reviewed

• Molecular Determinants for Activation of Human Ether-a-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide

  Garg, V., Weinzinger, A., Sachse, F. & Sanguinetti, M. C., 2011, In: Molecular Pharmacology. 80, 4, p. 630-637 8 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Physicochemical properties of pore residues predict activation gating of Ca(V)1.2: A correlation mutation analysis

  Beyl, S., Depil, K., Hohaus, A., Weinzinger, A., Timin, E., Shabbir, W., Kudrnac, M. & Hering, S., 2011, In: Pflügers Archiv: European Journal of Physiology. 461, 1, p. 53-63 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein.

  Depil, K., Beyl, S., Weinzinger, A., Hohaus, A., Timin, E. & Hering, S., 2011, In: Journal of Biological Chemistry. 286, 36, p. 31557-31564 8 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2010

  Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating: Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating.

  Karmazinova, M., Beyl, S., Weinzinger, A., Suwattanasophon, C., Klugbauer, N., Hering, S. & Lacinova, L., 2010, In: Pflügers Archiv: European Journal of Physiology. 460, 6, p. 1015-1028 14 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel

  de Boer, T., Nalos, L., Weinzinger, A., Kok, B., Houtman, M. J. C., Antoons, G., van Veen, T. A. B., Beekman, J. D. M., de Groot, B. L., Opthof, T., Rook, M. B., Vos, A. M. & van der Heyden, M. A. G., 2010, In: British Journal of Pharmacology. 159, 7, p. 1532-1541 10 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• The hERG potassium channel and drug trapping: insights from docking studies with propafenone derivatives: The hERG potassium channel and drug trapping: insight from docking studies with propafenone derivatives.

  Thai, K. M., Windisch, A., Stork, D., Weinzinger, A., Schiesaro, A., Guy, H. R., Timin, E., Hering, S. & Ecker, G., 2010, In: ChemMedChem: chemistry enabling drug discovery. 5, 3, p. 436-442 7 p.

  Publications: Contribution to journal › Article › Peer Reviewed