Dennis Kurzbach

2024

An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation

Kozak, F., Brandis, D., Pötzl, C., Epasto, L. M., Reichinger, D., Obrist, D., Peterlik, H., Polyansky, A., Zagrovic, B., Daus, F., Geyer, A., Becker, C. F. W. & Kurzbach, D., 14 Aug 2024, In: Advanced science. 11, 30, 2401239.

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Open Access

Branched Polymeric Prenucleation Assemblies Initiate Calcium Phosphate Precipitation

Turhan, E., Goldberga, I., Pötzl, C., Keil, W., Guigner, J. M., Haßler, M. F. T., Peterlik, H., Azaïs, T. & Kurzbach, D., 18 Sept 2024, In: Journal of the American Chemical Society. 146, 37, p. 25614-25624 11 p.

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Open Access

Hyperpolarized nuclear Overhauser enhancement of alanine methyl groups by doubly relayed proton exchange

Zachrdla, M., Turhan, E., Pötzl, C., Sadet, A., Vasos, P. R. & Kurzbach, D., Jul 2024, In: Journal of Magnetic Resonance. 364, 107727.

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Open Access

NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X

Epasto, L. M., Pötzl, C., Peterlik, H., Khalil, M., Saint-Pierre, C., Gasparutto, D., Sicoli, G. & Kurzbach, D., Jan 2024, In: Protein Science. 33, 1, e4849.

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Open Access

Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization

Turhan, E., Minaei, M., Narwal, P., Meier, B., Kouřil, K. & Kurzbach, D., Dec 2024, In: Communications Chemistry. 7, 1, 210.

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Open Access

Unified understanding of the breakdown of thermal mixing dynamic nuclear polarization: The role of temperature and radical concentration

Epasto, L. M., Maimbourg, T., Rosso, A. & Kurzbach, D., May 2024, In: Journal of Magnetic Resonance. 362, 107670.

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Open Access

2023

Biphasic NMR of Hyperpolarized Suspensions-Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow

Turhan, E., Pötzl, C., Keil, W., Negroni, M., Kouřil, K., Meier, B., Romero, J. A., Kazimierczuk, K., Goldberga, I., Azaïs, T. & Kurzbach, D., 5 Oct 2023, In: The Journal of Physical Chemistry Part C (Nanomaterials and Interfaces). 127, 39, p. 19591-19598 8 p.

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Open Access

Constraining and Modifying Peptides Using Pd-Mediated Cysteine Allylation

Kriegesmann, J., Schlatzer, T., Che, K., Altdorf, C., Huhmann, S., Kählig, H., Kurzbach, D., Breinbauer, R. & Becker, C. F. W., 3 Jul 2023, In: ChemBioChem. 24, 13, e202300098.

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Open Access

Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology

Strobl, J., Kozak, F., Kamalov, M., Reichinger, D., Kurzbach, D. & Becker, C. F. W., 16 Mar 2023, In: Advanced Materials. 35, 11, 11 p., 2207586.

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Open Access

2022

Frémy's Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging

Negroni, M., Turhan, E., Kress, T., Ceillier, M., Jannin, S. & Kurzbach, D., Nov 2022, In: Journal of the American Chemical Society. 144, 45, p. 20680-20686 7 p.

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Open Access

Hyperpolarized water as universal sensitivity booster in biomolecular NMR

Hilty, C., Kurzbach, D. & Frydman, L., May 2022, In: Nature Protocols. 17, 7, p. 1621-1657 37 p.

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Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

Hengxi, Z., Modenutti, C., Nekkanti, Y. P. K., Denis, M., Bermejo, I. A., Lefèbre, J., Che, K., Kim, D., Kagelmacher, M., Kurzbach, D., Nazaré, M. & Rademacher, C., 21 Oct 2022, In: ACS Chemical Biology. 17, 10, p. 2728–2733 6 p.

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Open Access

Inversion of Hyperpolarized ¹³C NMR Signals through Cross-Correlated Cross-Relaxation in Dissolution DNP Experiments

Negroni, M., Guarin, D., Che, K., Epasto, L. M., Turhan, E., Selimovic, A., Kozak, F., Cousin, S., Abergel, D., Bodenhausen, G. & Kurzbach, D., 8 Jun 2022, In: Journal of Physical Chemistry B. 126, 24, p. 4599-4610 12 p.

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Open Access

Nuclear Overhauser spectroscopy in hyperpolarized water - chemical vs. magnetic exchange

Epasto, L. M., Honegger, P., Che, K., Kozak, F., Jörg, F., Schröder, C. & Kurzbach, D., Sept 2022, In: Chemical Communications. 58, 83, p. 11661-11664 4 p.

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Open Access

Toward protein NMR at physiological concentrations by hyperpolarized water-Finding and mapping uncharted conformational spaces

Epasto, L. M., Che, K., Kozak, F., Selimovic, A., Kaderavek, P. & Kurzbach, D., 5 Aug 2022, In: Science Advances. 8, 31, 7 p., eabq5179.

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Open Access

2021

A novel sample handling system for dissolution dynamic nuclear polarization experiments

Kress, T., Che, K., Epasto, L. M., Kozak, F., Negroni, M., Olsen, G. L., Selimovic, A. & Kurzbach, D., 4 Jun 2021, In: Magnetic Resonance. 2, 1, p. 387–394 8 p.

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Open Access

Conformational selection of vasopressin upon V_1a receptor binding

Che, K., Muttenthaler, M. & Kurzbach, D., Jan 2021, In: Computational and Structural Biotechnology Journal. 19, p. 5826-5833 8 p.

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Open Access

Formation and Evolution of Nanoscale Calcium Phosphate Precursors under Biomimetic Conditions

Epasto, L. M., Georges, T., Selimovic, A., Guigner, J-M., Azais, T. & Kurzbach, D., 27 Jul 2021, In: Analytical Chemistry. 93, 29, p. 10204-10211 8 p.

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Open Access

Ingredient-Dependent Extent of Lipid Oxidation in Margarine

Fruehwirth, S., Egger, S., Kurzbach, D., Windisch, J., Jirsa, F., Flecker, T., Ressler, M., Reiner, A. T., Firat, N. & Pignitter, M., 13 Jan 2021, In: Antioxidants. 10, 1, p. 1-17 17 p., 105.

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Open Access

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Dekan, Z., Kremsmayr, T., Keov, P., Godin, M., Teakle, N., Durrauer, L., Xiang, H., Gharib, D., Bergmayr, C., Hellinger, R., Gay, M., Vilaseca, M., Kurzbach, D., Albericio, F., Alewood, P. F., Gruber, C. W. & Muttenthaler, M., 21 Mar 2021, In: Chemical Science. 12, 11, p. 4057-4062 6 p.

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Open Access

Residue-resolved monitoring of protein hyperpolarization at sub-second time resolution

Negroni, M. & Kurzbach, D., 22 Oct 2021, In: Communications Chemistry. 4, 1, 7 p., 147.

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Open Access

2020

¹H, ¹³C and ¹⁵N backbone resonance assignment of BRCA1 fragment 219–504

Gorka, M., Zerko, S., Konrat, R., Kozminski, W. & Kurzbach, D., 24 Jun 2020, In: Biomolecular NMR Assignments. 14, p. 289–293 5 p.

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Open Access

Assessing the Onset of Calcium Phosphate Nucleation by Hyperpolarized Real-Time NMR

Weber, E. M. M., Kress, T., Abergel, D., Sewsurn, S., Azais, T. & Kurzbach, D., 2 Jun 2020, In: Analytical Chemistry. 92, 11, p. 7666-7673 8 p.

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Open Access

A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix-Loop-Helix Transcription Factor

Sicoli, G., Kress, T., Vezin, H., Ledolter, K. & Kurzbach, D., 5 Nov 2020, In: The Journal of Physical Chemistry Letters. 11, 21, p. 8944-8951 8 p.

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Open Access

Hyperpolarized NMR Metabolomics at Natural 13C Abundance

Dey, A., Charrier, B., Martineau, E., Deborde, C., Gandriau, E., Moing, A., Jacob, D., Eshchenko, D., Schnell, M., Melzi, R., Kurzbach, D., Ceillier, M., Chappuis, Q., Cousin, S. F., Kempf, J. G., Jannin, S., Dumez, J-N. & Giraudeau, P., 17 Nov 2020, In: Analytical Chemistry. 92, 22, p. 14867-14871 5 p.

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Open Access

Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis

Ozcan, A., Sahin, D., Impellizzieri, D., Nguyen, T. T., Hafner, J., Yawalkar, N., Kurzbach, D., Tan, G., Akdis, C. A., Nilsson, J., Boyman, O. & Kolios, A. G. A., May 2020, In: Journal of Investigative Dermatology. 140, 5, p. 1003-1014.e8 e8.

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Open Access

NMR for food profiling – Long Drink, Short Experiment: Ein interdisziplinärer Zugang zur Förderung von Urteilskompetenz

Groß, K., Kurzbach, D. & Angele, C. M., 2020, In: Haushalt in Bildung und Forschung. 9, 4, p. 79-96 18 p.

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Sensitivity-enhanced three-dimensional and carbon-detected two-dimensional NMR of proteins using hyperpolarized water

Olsen, G. L., Szekely, O., Mateos, B., Kaderavek, P., Ferrage, F., Konrat, R., Pierattelli, R., Felli, I. C., Bodenhausen, G., Kurzbach, D. & Frydman, L., Mar 2020, In: Journal of Biomolecular NMR. 74, 2-3, p. 161-171 11 p.

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Open Access

2019

A DNP-hyperpolarized solid-state water NMR MASER: observation and qualitative analysis

Weber, E. M. M., Kurzbach, D. & Abergel, D., 14 Oct 2019, In: Physical Chemistry Chemical Physics. 21, 38, p. 21278-21286 9 p.

Publications: Contribution to journal › Article › Peer Reviewed

Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts

Jannin, S., Dumez, J-N., Giraudeau, P. & Kurzbach, D., Aug 2019, In: Journal of Magnetic Resonance. 305, p. 41-50 10 p.

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Conformational tuning of a DNA-bound transcription factor

Sicoli, G., Vezin, H., Ledolter, K., Kress, T. & Kurzbach, D., 4 Jun 2019, In: Nucleic Acids Research. 47, 10, p. 5429-5435 7 p.

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Open Access

Hyperpolarized Water Enhances Two-Dimensional Proton NMR Correlations: A New Approach for Molecular Interactions

Sadet, A., Stavarache, C., Bacalum, M., Radu, M., Bodenhausen, G., Kurzbach, D. & Vasos, P. R., 14 Aug 2019, In: Journal of the American Chemical Society. 141, 32, p. 12448-12452 5 p.

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Long-Lived States in Hyperpolarized Deuterated Methyl Groups Reveal Weak Binding of Small Molecules to Proteins

Kress, T., Walrant, A., Bodenhausen, G. & Kurzbach, D., 4 Apr 2019, In: Journal of Physical Chemistry Letters. 10, 7, p. 1523-1529 7 p.

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Transport of hyperpolarized samples in dissolution-DNP experiments

Kiryutin, A. S., Rodin, B. A., Yurkovskaya, A. V., Ivanov, K. L., Kurzbach, D., Jannin, S., Guarin, D., Abergel, D. & Bodenhausen, G., 7 Jul 2019, In: Physical Chemistry Chemical Physics. 21, 25, p. 13696-13705 10 p.

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Open Access

2018

Dissolution Dynamic Nuclear Polarization Methodology and Instrumentation

Kurzbach, D. & Jannin, S., 2018, In: eMagRes. 7, 4, p. 117-131 15 p.

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High-Resolution NMR of Folded Proteins in Hyperpolarized Physiological Solvents

Kadeřávek, P., Ferrage, F., Bodenhausen, G. & Kurzbach, D., 12 Sept 2018, In: Chemistry: A European Journal. 24, 51, p. 13418-13423 6 p.

Publications: Contribution to journal › Article › Peer Reviewed

Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism

Beier, A., Schwarz, T. C., Kurzbach, D., Platzer, G., Tribuzio, F. & Konrat, R., 3 Aug 2018, In: Journal of Molecular Biology. 430, 16, p. 2439-2452 14 p.

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Rates of Chemical Reactions Embedded in a Metabolic Network by Dissolution Dynamic Nuclear Polarisation NMR

Sadet, A., Weber, E. M. M., Jhajharia, A., Kurzbach, D., Bodenhausen, G., Miclet, E. & Abergel, D., 11 Apr 2018, In: Chemistry: A European Journal. 24, 21, p. 5456-5461 6 p.

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Relaxation of long-lived modes in NMR of deuterated methyl groups

Ivanov, K. L., Kress, T., Baudin, M., Guarin, D., Abergel, D., Bodenhausen, G. & Kurzbach, D., 7 Aug 2018, In: Journal of Chemical Physics. 149, 5, 9 p., 054202.

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Sample Ripening through Nanophase Separation Influences the Performance of Dynamic Nuclear Polarization

Weber, E. M. M., Sicoli, G., Vezin, H., Frebourg, G., Abergel, D., Bodenhausen, G. & Kurzbach, D., 23 Apr 2018, In: Angewandte Chemie (International Edition). 57, 18, p. 5171-5175 5 p.

Publications: Contribution to journal › Article › Peer Reviewed

2017

Anisotropic longitudinal electronic relaxation affects DNP at cryogenic temperatures

Weber, E. M. M., Vezin, H., Kempf, J. G., Bodenhausen, G., Abergel, D. & Kurzbach, D., 28 Jun 2017, In: Physical Chemistry Chemical Physics. 19, 24, p. 16087-16094 8 p.

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Characterizing Thermal Mixing Dynamic Nuclear Polarization via Cross-Talk between Spin Reservoirs

Guarin, D., Marhabaie, S., Rosso, A., Abergel, D., Bodenhausen, G., Ivanov, K. L. & Kurzbach, D., 16 Nov 2017, In: Journal of Physical Chemistry Letters. 8, 22, p. 5531-5536 6 p.

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Communication: Dissolution DNP reveals a long-lived deuterium spin state imbalance in methyl groups

Jhajharia, A., Weber, E. M. M., Kempf, J. G., Abergel, D., Bodenhausen, G. & Kurzbach, D., 28 Jan 2017, In: Journal of Chemical Physics. 146, 4, 4 p., 041101.

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Open Access

Hydrophobic Collapse of the Intrinsically Disordered Transcription Factor Myc Associated Factor X

Kizilsavas, G., Ledolter, K. & Kurzbach, D., 10 Oct 2017, In: Biochemistry. 56, 40, p. 5365-5372 8 p.

Publications: Contribution to journal › Article › Peer Reviewed

Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water

Kurzbach, D., Canet, E., Flamm, A. G., Jhajharia, A., Weber, E. M. M., Konrat, R. & Bodenhausen, G., 2 Jan 2017, In: Angewandte Chemie (International Edition). 56, 1, p. 389-392 4 p.

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NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins

Kurzbach, D., Beier, A., Vanas, A., Flamm, A. G., Platzer, G., Schwarz, T. C. & Konrat, R., 28 Mar 2017, In: Physical Chemistry Chemical Physics. 19, 16, p. 10651-10656 6 p.

Publications: Contribution to journal › Article › Peer Reviewed

Single-Scan ¹³C Diffusion-Ordered NMR Spectroscopy of DNP-Hyperpolarised Substrates

Guduff, L., Kurzbach, D., van Heijenoort, C., Abergel, D. & Dumez, J-N., 27 Nov 2017, In: Chemistry: A European Journal. 23, 66, p. 16722-16727 6 p.

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2016

Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference

Kurzbach, D., Vanas, A., Flamm, A. G., Tarnoczi, N., Kontaxis, G., Maltar-Strmečki, N., Widder, K., Hinderberger, D. & Konrat, R., 2016, In: Physical Chemistry Chemical Physics. 18, 8, p. 5753-5758 6 p.

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Open Access

Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization

Kurzbach, D., Weber, E. M. M., Jhajharia, A., Cousin, S. F., Sadet, A., Marhabaie, S., Canet, E., Birlirakis, N., Milani, J., Jannin, S., Eshchenko, D., Hassan, A., Melzi, R., Luetolf, S., Sacher, M., Rossire, M., Kempf, J., Lohman, J. A. B., Weller, M., Bodenhausen, G., & 1 othersAbergel, D., 21 Nov 2016, In: Journal of Chemical Physics. 145, 19, 8 p., 194203.

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Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

Vuichoud, B., Bornet, A., de Nanteuil, F., Milani, J., Canet, E., Ji, X., Mieville, P., Weber, E., Kurzbach, D., Flamm, A., Konrat, R., Gossert, A. D., Jannin, S. & Bodenhausen, G., Oct 2016, In: Chemistry: A European Journal. 22, 41, p. 14696-14700 5 p.

Publications: Contribution to journal › Article › Peer Reviewed

Dennis Kurzbach

Publications

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