Haider Sami

2025

Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction

Weiss, S., Decker, S., Kugler, C., Gómez, L. B., Fasching, H., Benisch, D., Alioglu, F., Ferencz, L., Birkfeld, T., Ilievski, F., Baumann, V., Duran, A., Dusinovic, E., Follrich, N., Milenkovic, S., Mihalicokova, D., Paunov, D., Singeorzan, K., Zehetmayer, N., Zivanonvic, D., & 5 othersLächelt, U., Boersma, A., Rülicke, T., Sami, H. & Ogris, M., 12 Feb 2025, In: ACS applied materials & interfaces. 17, 6, p. 9000-9018 19 p.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

2023

A Versatile Brij-Linker for One-Step Preparation of Targeted Nanoparticles

Anzengruber, M., Nepustil, L. M., Kurtaj, F., Tahir, A., Skoll, K., Sami, H., Wirth, M. & Gabor, F., May 2023, In: Pharmaceutics. 15, 5, 1403.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Control of cell penetration enhancer shielding and endosomal escape-kinetics crucial for efficient and biocompatible siRNA delivery

Malfanti, A., Sami, H., Balasso, A., Marostica, G., Arpac, B., Mastrotto, F., Mantovani, G., Cola, E., Anton, M., Caliceti, P., Ogris, M. & Salmaso, S., Nov 2023, In: Journal of Controlled Release. 363, p. 101-113 13 p.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo

Strasser, P., Montsch, B., Weiss, S., Sami, H., Kugler, C., Hager, S., Schueffl, H., Mader, R., Brüggemann, O., Kowol, C. R., Ogris, M., Heffeter, P. & Teasdale, I., 1 Jun 2023, In: Small. 19, 22, 2300767.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

2022

Endothelial Retargeting of AAV9 In Vivo

Bozoglu, T., Lee, S., Ziegler, T., Jurisch, V., Maas, S., Baehr, A., Hinkel, R., Hoenig, A., Hariharan, A., Kim, C. I., Decker, S., Sami, H., Koppara, T., Oellinger, R., Müller, O. J., Frank, D., Megens, R., Nelson, P., Weber, C., Schnieke, A., & 8 othersSperandio, M., Santamaria, G., Rad, R., Moretti, A., Laugwitz, K. L., Soehnlein, O., Ogris, M. & Kupatt, C., 4 Mar 2022, In: Advanced Science. 9, 7, 12 p., 2103867.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Investigating 3R In Vivo Approaches for Bio-Distribution and Efficacy Evaluation of Nucleic Acid Nanocarriers: Studies on Peptide-Mimicking Ionizable Lipid

Giselbrecht, J., Pinnapireddy, S. R., Alioglu, F., Sami, H., Sedding, D., Erdmann, F., Janich, C., Schulz-Siegmund, M., Ogris, M., Bakowsky, U., Langner, A., Bussmann, J. & Wölk, C., 30 Mar 2022, In: Small. 18, 18, 16 p., 2107768.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Structure-based peptide ligand design for improved epidermal growth factor receptor targeted gene delivery

Decker, S., Taschauer, A., Geppl, E., Pirhofer, V., Schauer, M., Pöschl, S., Kopp, F., Richter, L., Ecker, G. F., Sami, H. & Ogris, M., Jul 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 176, p. 211-221 11 p.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

2021

CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

Billerhart, M., Schonhofer, M., Schueffl, H., Polzer, W., Decker, S., Taschauer, A., Maier, J., Anton, M., Eckmann, S., Blaschek, M., Pichler, J., Heffeter, P., Sami, H. & Ogris, M., 17 Dec 2021, In: Molecular therapy-Oncolytics. 23, p. 192-204 13 p.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Surface modification of e. Coli outer membrane vesicles with glycosylphosphatidylinositol-anchored proteins: Generating pro/eukaryote chimera constructs

Zaruba, M., Roschitz, L., Sami, H., Ogris, M., Gerner, W. & Metzner, C., Jun 2021, In: Membranes. 11, 6, 16 p., 428.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

2020

Combined Chemisorption and Complexation Generate siRNA Nanocarriers with Biophysics Optimized for Efficient Gene Knockdown and Air-Blood Barrier Crossing

Taschauer, A., Polzer, W., Poeschl, S., Metz, S., Tepe, N., Decker, S., Cyran, N., Scholda, J., Maier, J., Bloss, H., Anton, M., Hofmann, T., Ogris, M. & Sami, H., 9 Jun 2020, In: ACS applied materials & interfaces. 12, 27, p. 30095-30111 17 p.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

2019

Firefly luciferase-based reporter gene assay for investigating nanoparticle-mediated nucleic acid delivery

Müller, K., Ogris, M. & Sami, H., 1 Jan 2019, Methods in Molecular Biology. Humana Press, Inc., p. 227-239 13 p. (Methods in Molecular Biology, Vol. 1943).

Publications: Contribution to book › Chapter › Peer Reviewed

Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway

Maier, J., Elmenofi, S., Taschauer, A., Anton, M., Sami, H. & Ogris, M., 2019, In: PLoS ONE. 14, 12, 23 p., e0226570.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, H., Nielsen, H. M., Braeckmans, K., Lehr, C-M., Ogris, M. & Foged, C., 28 Sept 2019, In: Journal of Controlled Release. 310, p. 82-93 12 p.

Publications: Contribution to journal › Article › Peer Reviewed

Nanoparticle functionalized polyplexes: efficient nucleic acid delivery platform and theranostic applications

Sami, H., Taschauer, A., Tepe, N., Decker, S., Cyran, N., Anton, M., Hofmann, T., Rogach, A. & Ogris, M., 2019. 1 p.

Publications: Contribution to conference › Other contribution to conference

Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung

Taschauer, A., Polzer, W., Alioglu, F., Billerhart, M., Decker, S., Kittelmann, T., Geppl, E., Elmenofi, S., Zehl, M., Urban, E., Sami, H. & Ogris, M., 6 Dec 2019, In: Molecular Therapy - Nucleic Acids. 18, p. 774-786 13 p.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Water-Soluble NHC Stabilized Gold Nanoparticles

Reithofer, M., Chin, J. M., Young, A. J., Sami, H., Eisen, C., Rubio, G., Tepe, N., Hofmann, T., Ogris, M. & Keppler, B., 11 Aug 2019, Book of Abstracts. p. IL-080

Publications: Contribution to book › Contribution to proceedings › Peer Reviewed

2017

Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells

Wittig, A., Gehrke, H., Del Favero, G., Fritz, E-M., Al-Rawi, M., Diabate, S., Weiss, C., Sami, H., Ogris, M. & Marko, D., Jan 2017, In: Nanomaterials. 7, 1, 26 p., 18.

Publications: Contribution to journal › Article › Peer Reviewed

Open Access

Fluorescence- and computed tomography for assessing the biodistribution of siRNA after intratracheal application in mice

Geyer, A., Lorenzer, C., Gehrig, S., Simlinger, M., Winkler, J., Sami, H. & Ogris, M., 20 Jun 2017, In: International Journal of Pharmaceutics. 525, 2, p. 359-366 8 p.

Publications: Contribution to journal › Article › Peer Reviewed

Multimodal Fluorescence and Bioluminescence Imaging Reveals Transfection Potential of Intratracheally Administered Polyplexes for Breast Cancer Lung Metastases

Geyer, A., Taschauer, A., Alioglu, F., Anton, M., Maier, J., Drothler, E., Simlinger, M., Yavuz, S., Sami, H. & Ogris, M., Dec 2017, In: Human Gene Therapy. 28, 12, p. 1202-1213 12 p.

Publications: Contribution to journal › Article › Peer Reviewed

Quantoplexes to track nucleic acid delivery: biophysical properties, cell uptake and transfection in vitro and 3D-optical imaging in vivo

Sami, H., Gehrig, S., Taschauer, A., Geyer, A., Billerhart, M., Yavuz, S., Schutzhofer, A., Alioglu, F., Susha, A., Rogach, A. & Ogris, M., Dec 2017, In: Human Gene Therapy. 28, 12, p. A119-A120 2 p.

Publications: Contribution to journal › Meeting abstract/Conference paper › Peer Reviewed

2016