Robert Konrat

Publications

Publications per year 2000 2000 2001 2004 2007 2009 2010 2011 2013 2014 2016 2017 2018 2020 2021 2024 2024

• 120 Article
• 6 Short communication
• 1 Contribution to proceedings
• 1 Meeting abstract/Conference paper
• 2 More
  • 1 Correction
  • 1 Review

Publications per year

Publications per year

Search results

• 2024

  Decorating phenylalanine side-chains with triple labeled ¹³C/¹⁹F/²H isotope patterns

  Toscano, G., Holzinger, J., Nagl, B., Kontaxis, G., Kählig, H., Konrat, R. & Lichtenecker, R. J., Mar 2024, (E-pub ahead of print) In: Journal of Biomolecular NMR.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Probing Protein-Ligand Methyl−π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups

  Beier, A., Platzer, G., Höfurthner, T., Ptaszek, A. L., Lichtenecker, R. J., Geist, L., Fuchs, J. E., McConnell, D. B., Mayer, M. & Konrat, R., 8 Aug 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13187-13196 10 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail

  Vogl, D. P., Mateos, B., Migotti, M., Felkl, M., Conibear, A. C., Konrat, R. & Becker, C. F. W., 15 Feb 2024, In: Bioorganic and Medicinal Chemistry. 100, 117617.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Synthesis of a ¹³C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics

  Höfurthner, T., Toscano, G., Kontaxis, G., Beier, A., Mayer, M., Geist, L., McConnell, D. B., Weinstabl, H., Lichtenecker, R. & Konrat, R., Mar 2024, In: Journal of Biomolecular NMR. 78, 1, p. 1-8 8 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

  • Synthesis 100%
  • Isoleucine 100%
  • Dynamics 100%
  • Precursor 100%
  • Protein 100%

• Towards cost-effective side-chain isotope labelling of proteins expressed in human cells

  Rosati, M., Barbieri, L., Hlavac, M., Kratzwald, S., Lichtenecker, R. J., Konrat, R., Luchinat, E. & Banci, L., 2024, (E-pub ahead of print) In: Journal of Biomolecular NMR.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2023

  Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

  Klussmann, J. P., Grosheva, M., Meiser, P., Lehmann, C., Nagy, E., Szijártó, V., Nagy, G., Konrat, R., Flegel, M., Holzer, F., Groß, D., Steinmetz, C., Scherer, B., Gruell, H., Schlotz, M., Klein, F., de Aragão, P. A., Morr, H., Al Saleh, H., Bilstein, A., & 7 othersRusso, B., Müller-Scholtz, S., Acikel, C., Sahin, H., Werkhäuser, N., Allekotte, S. & Mösges, R., 26 Apr 2023, In: Scientific Reports. 13, 1, 12 p., 6839.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599

  Schwarz, T. C., Beier, A., Ledolter, K., Gossenreiter, T., Höfurthner, T., Hartl, M., Baker, T. S., Taylor, R. J. & Konrat, R., 11 Apr 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 15, e2201910120.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes

  Shchukina, A., Schwarz, T. C., Nowakowski, M., Konrat, R. & Kazimierczuk, K., Aug 2023, In: Journal of Biomolecular NMR. 77, 4, p. 149-163 15 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

  • Uniform Sampling 100%
  • Liposome 100%
  • Nonlinear Behavior 16%

• Studies of proline conformational dynamics in IDPs by ¹³C-detected cross-correlated NMR relaxation

  Schiavina, M., Konrat, R., Ceccolini, I., Mateos, B., Konrat, R., Felli, I. C. & Pierattelli, R., Sep 2023, In: Journal of Magnetic Resonance. 354, 8 p., 107539.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2022

  Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD

  Feichtinger, M., Beier, A., Migotti, M., Schmid, M., Bokhovchuk, F., Chène, P. & Konrat, R., 15 Apr 2022, In: Iscience. 25, 4, 104099.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue

  Konrat, R., Papp, H., Kimpel, J., Rössler, A., Szijártó, V., Nagy, G., Madai, M., Zeghbib, S., Kuczmog, A., Lanszki, Z., Gesell, T., Helyes, Z., Kemenesi, G., Jakab, F. & Nagy, E., 30 Jun 2022, In: Frontiers in Pharmacology. 13, 861295.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2021

  A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods

  Brüschweiler, S., Fuchs, J. E., Bader, G., McConnell, D. B., Konrat, R. & Mayer, M., 6 Dec 2021, In: ChemMedChem. 16, 23, p. 3576-3587 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Binding Mode Characterization of Osteopontin on Hydroxyapatite by Solution NMR Spectroscopy

  Holzinger, J., Kotisch, H., Richter, K. W. & Konrat, R., 1 Jul 2021, In: ChemBioChem: a european journal of chemical biology. 22, 13, p. 2300-2305 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Cosolute modulation of protein oligomerization reactions in the homeostatic timescale

  Mateos, B., Bernardo-Seisdedos, G., Dietrich, V., Zalba, N., Ortega, G., Peccati, F., Jiménez-Osés, G., Konrat, R., Tollinger, M. & Millet, O., 18 May 2021, In: Biophysical Journal. 120, 10, p. 2067-2077 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition

  Mateos, B., Holzinger, J., Conrad-Billroth, C., Platzer, G., Żerko, S., Sealey-Cardona, M., Anrather, D., Koźmiński, W. & Konrat, R., 20 Apr 2021, In: Biochemistry. 60, 17, p. 1347-1355 9 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR

  Amos, S. B. T. A., Schwarz, T. C., Shi, J., Cossins, B. P., Baker, T. S., Taylor, R. J., Konrat, R. & Sansom, M. S. P., 15 Mar 2021, In: Journal of Physical Chemistry B. 125, 11, p. 2929-2941 13 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Molecular basis of F-actin regulation and sarcomere assembly via myotilin

  Kostan, J., Pavšič, M., Puž, V., Schwarz, T. C., Drepper, F., Molt, S., Graewert, M. A., Schreiner, C., Sajko, S., van der Ven, P. F. M., Onipe, A., Svergun, D. I., Warscheid, B., Konrat, R., Fürst, D. O., Lenarčič, B. & Djinović-Carugo, K., 12 Apr 2021, In: PLoS Biology. 19, 4, 34 p., e3001148.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin

  Sponga, A., Arolas, J. L., Schwarz, T. C., Jeffries, C. M., Chamorro, A. R., Kostan, J., Ghisleni, A., Drepper, F., Polyansky, A., de Almeida Ribeiro, E., Pedron, M., Zawadzka-Kazimierczuk, A., Mlynek, G., Peterbauer, T., Doto, P., Schreiner, C., Hollerl, E., Mateos, B., Geist, L., Faulkner, G., & 7 othersKozminski, W., Svergun, D. I., Warscheid, B., Zagrovic, B., Gautel, M., Konrat, R. & Djinović-Carugo, K., 28 May 2021, In: Science Advances. 7, 22, 19 p., eabg7653.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Temperature as an Extra Dimension in Multidimensional Protein NMR Spectroscopy

  Shchukina, A., Małecki, P., Mateos, B., Nowakowski, M., Urbańczyk, M., Kontaxis, G., Kasprzak, P., Conrad-Billroth, C., Konrat, R. & Kazimierczuk, K., Jan 2021, In: Chemistry: A European Journal. 27, 5, p. 1753-1767 15 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Using Cross-Correlated Spin Relaxation to Characterize Backbone Dihedral Angle Distributions of Flexible Protein Segments

  Kauffmann, C., Zawadzka-Kazimierczuk, A., Kontaxis, G. & Konrat, R., 7 Jan 2021, In: ChemPhysChem: a European journal of chemical physics and physical chemistry. 22, 1, p. 18-28 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access
• 2020

  19F NMR Spectroscopy Tagging and Paramagnetic Relaxation Enhancement-Based Conformation Analysis of Intrinsically Disordered Protein Complexes

  Somlyay, M., Ledolter, K., Kitzler, M., Sandford, G., Cobb, S. L. & Konrat, R., 2 Mar 2020, In: ChemBioChem: a european journal of chemical biology. 21, 5, p. 696-701 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• ¹H, ¹³C and ¹⁵N backbone resonance assignment of BRCA1 fragment 219–504

  Gorka, M., Zerko, S., Konrat, R., Kozminski, W. & Kurzbach, D., 24 Jun 2020, In: Biomolecular NMR Assignments. 14, p. 289–293 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• A novel high-dimensional NMR experiment for resolving protein backbone dihedral angle ambiguities

  Kauffmann, C., Kazimierczuk, K., Schwarz, T. C., Konrat, R. & Zawadzka-Kazimierczuk, A., 1 Apr 2020, In: Journal of Biomolecular NMR. 74, 4-5, p. 257-265 9 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• NMR Characterization of Surface Receptor Protein Interactions in Live Cells Using Methylcellulose Hydrogels

  Mateos, B., Sealey-Cardona, M., Balazs, K., Konrat, J., Staffler, G. & Konrat, R., 2 Mar 2020, In: Angewandte Chemie (International Edition). 59, 10, p. 3886-3890 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Osteopontin regulates biomimetic calcium phosphate crystallization from disordered mineral layers covering apatite crystallites

  Iline-Vul, T., Nanda, R., Mateos, B., Hazan, S., Matlahov, I., Perelshtein, I., Keinan-Adamsky, K., Althoff-Ospelt, G., Konrat, R. & Goobes, G., 24 Sep 2020, In: Scientific Reports. 10, 1, 16 p., 15722.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• PI by NMR: Probing CH–π Interactions in Protein–Ligand Complexes by NMR Spectroscopy

  Platzer, G., Mayer, M., Beier, A., Brüschweiler, S., Fuchs, J. E., Engelhardt, H., Geist, L., Bader, G., Schoerghuber, J., Lichtenecker, R., Wolkerstorfer, B., Kessler, D., McConnell, D. B. & Konrat, R., 24 Aug 2020, In: Angewandte Chemie (International Edition). 59, 35, p. 14861-14868 8 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Sensitivity-enhanced three-dimensional and carbon-detected two-dimensional NMR of proteins using hyperpolarized water

  Olsen, G. L., Szekely, O., Mateos, B., Kaderavek, P., Ferrage, F., Konrat, R., Pierattelli, R., Felli, I. C., Bodenhausen, G., Kurzbach, D. & Frydman, L., Mar 2020, In: Journal of Biomolecular NMR. 74, 2-3, p. 161-171 11 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• The Ambivalent Role of Proline Residues in an Intrinsically Disordered Protein: From Disorder Promoters to Compaction Facilitators

  Mateos, B., Conrad-Billroth, C., Schiavina, M., Beier, A., Kontaxis, G., Konrat, R., Felli, I. C. & Pierattelli, R., 17 Apr 2020, In: Journal of Molecular Biology. 432, 9, p. 3093-3111 19 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2019

  ¹H, ¹⁵N, ¹³C resonance assignment of the human CD44 cytoplasmic tail (669–742)

  Frühbauer, B., Mateos, B. & Konrat, R., Apr 2019, In: Biomolecular NMR Assignments. 13, 1, p. 109–113 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Binding of the protein ICln to α-integrin contributes to the activation of ICl _swell current

  Schedlbauer, A., Tammaz, G., Rodighiero, S., Civello, D. A., Tamplenizza, M., Ledolter, K., Nofziger, C., Patsch, W., Konrat, R., Paulmichl, M. & Dossena, S., 21 Aug 2019, In: Scientific Reports. 9, 1, 16 p., 12195.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Correction: ¹⁹F multiple-quantum coherence NMR spectroscopy for probing protein-ligand interactions (RSC Advances (2018) 8 (40687-40692) DOI: 10.1039/C8RA09296F)

  Zawadzka-Kazimierczuk, A., Somlyay, M., Kaehlig, H., Iakobson, G., Beier, P. & Konrat, R., 24 Jan 2019, In: RSC Advances . 9, 6, p. 3503-3503 1 p.

  Publications: Contribution to journal › Correction › Peer Reviewed

  Open Access

• NMR Characterization of Long‐Range Contacts in Intrinsically Disordered Proteins from Paramagnetic Relaxation Enhancement in 13C Direct‐Detection Experiments

  Mateos, B., Konrat, R., Pieratelli, R. & Felli, I. C., 1 Feb 2019, In: ChemBioChem: a european journal of chemical biology. 20, 3, p. 335-339 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2018

  19F multiple- quantum coherence NMR spectroscopy for probing protein- ligand interactions

  Zawadzka-Kazimierczuk, A., Somlyay, M., Kaehlig, H., Iakobson, G., Beier, P. & Konrat, R., 2018, In: RSC Advances . 8, 71, p. 40687-40692 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• 1H, 13C, 15N resonance assignment of human YAP 50–171 fragment

  Feichtinger, M., Sara, T., Platzer, G., Mateos, B., Bokhovchuk, F., Chène, P. & Konrat, R., Apr 2018, In: Biomolecular NMR Assignments. 12, 1, p. 179-182 4 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Biodegradation of pentafluorosulfanyl-substituted aminophenol in Pseudomonas spp.

  Saccomanno, M., Hussain, S., O'Connor, N. K., Beier, P., Somlyay, M., Konrat, R. & Murphy, C. D., Jun 2018, In: Biodegradation. 29, 3, p. 259-270 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  • Toxic 100%
  • Ion 100%
  • Aminophenol 100%
  • Fluoride 100%
  • Metabolite 100%

• Late metabolic precursors for selective aromatic residue labeling

  Schoerghuber, J., Geist, L., Platzer, G., Feichtinger, M., Bisaccia, M., Scheibelberger, L., Weber, F., Konrat, R. & Lichtenecker, R. J., Jul 2018, In: Journal of Biomolecular NMR. 71, 3, p. 129-140 12 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism

  Beier, A., Schwarz, T. C., Kurzbach, D., Platzer, G., Tribuzio, F. & Konrat, R., 3 Aug 2018, In: Journal of Molecular Biology. 430, 16, p. 2439-2452 14 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  • Regulatory Mechanism 100%
  • Intrinsically Disordered Protein 100%
  • Complex Formation 100%
  • Modulation 100%
  • Conformational Ensembles 12%
• 2017

  A histone-mimicking interdomain linker in a multi-domain protein modulates multivalent histone binding

  Kostrhon, S., Kontaxis, G., Kaufmann, T., Schirghuber, E., Kubicek, S., Konrat, R. & Slade, D., 27 Oct 2017, In: Journal of Biological Chemistry. 292, 43, p. 17643-17657 15 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Anthranilic acid, the new player in the ensemble of aromatic residue labeling precursor compounds

  Schoerghuber, J., Geist, L., Bisaccia, M., Weber, F., Konrat, R. & Lichtenecker, R. J., Sep 2017, In: Journal of Biomolecular NMR. 69, 1, p. 13-22 10 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Calcium-dependent binding of Myc to calmodulin.

  Schwarz, T., Konrat, R. & Ledolter, K., 2017, In: Oncotarget. 2017

  Publications: Contribution to journal › Article › Peer Reviewed

• Highly Selective Stable Isotope Labeling of Histidine Residues by Using a Novel Precursor in E. coli-Based Overexpression Systems

  Schoerghuber, J., Geist, L., Platzer, G., Konrat, R. & Lichtenecker, R. J., 4 Aug 2017, In: ChemBioChem: a european journal of chemical biology. 18, 15, p. 1487-1491 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water

  Kurzbach, D., Canet, E., Flamm, A. G., Jhajharia, A., Weber, E. M. M., Konrat, R. & Bodenhausen, G., 2 Jan 2017, In: Angewandte Chemie (International Edition). 56, 1, p. 389-392 4 p.

  Publications: Contribution to journal › Article › Peer Reviewed

• New approaches toward selective labeling of aromatic residues in cell-based overexpression media

  Schörghuber, J., Geist, L., Bisaccia, M., Weber, F., Sara, T., Konrat, R., Schmid, W. & Lichtenecker, R., 6 Mar 2017, AILM2017 conference book. p. S12

  Publications: Contribution to book › Contribution to proceedings

• NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins

  Kurzbach, D., Beier, A., Vanas, A., Flamm, A. G., Platzer, G., Schwarz, T. C. & Konrat, R., 28 Mar 2017, In: Physical Chemistry Chemical Physics. 19, 16, p. 10651-10656 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed
• 2016

  ¹H, ¹⁵N, ¹³C resonance assignment of human GAP-43

  Flamm, A. G., Żerko, S., Zawadzka-Kazimierczuk, A., Koźmiński, W., Konrat, R. & Coudevylle, N., 1 Apr 2016, In: Biomolecular NMR Assignments. 10, 1, p. 171-174 4 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.

  Schwarz, T., Konrat, R. & Ledolter, K., 2016, In: Brain: a journal of neurology. 2016

  Publications: Contribution to journal › Article › Peer Reviewed

• Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17

  Cabedo Martinez, A-I., Weinhaupl, K., Lee, W-K., Wolff, N. A., Storch, B., Żerko, S., Konrat, R., Koźmiński, W., Breuker, K., Thévenod, F. & Coudevylle, N., 5 Feb 2016, In: Journal of Biological Chemistry. 291, 6, p. 2917-2930 14 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Detection of correlated conformational fluctuations in intrinsically disordered proteins through paramagnetic relaxation interference

  Kurzbach, D., Vanas, A., Flamm, A. G., Tarnoczi, N., Kontaxis, G., Maltar-Strmečki, N., Widder, K., Hinderberger, D. & Konrat, R., 2016, In: Physical Chemistry Chemical Physics. 18, 8, p. 5753-5758 6 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Excited States of Nucleic Acids Probed by Proton Relaxation Dispersion NMR Spectroscopy

  Juen, M. A., Wunderlich, C. H., Nußbaumer, F., Tollinger, M., Kontaxis, G., Konrat, R., Hansen, D. F. & Kreutz, C., 19 Sep 2016, In: Angewandte Chemie (International Edition). 55, 39, p. 12008-12012 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed

  Open Access

• Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

  Vuichoud, B., Bornet, A., de Nanteuil, F., Milani, J., Canet, E., Ji, X., Mieville, P., Weber, E., Kurzbach, D., Flamm, A., Konrat, R., Gossert, A. D., Jannin, S. & Bodenhausen, G., Oct 2016, In: Chemistry: A European Journal. 22, 41, p. 14696-14700 5 p.

  Publications: Contribution to journal › Article › Peer Reviewed