ß-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides

Johannes Winkler; Ernst Urban; Christian Noe

doi:10.1007/s00706-003-0086-1

ß-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides

Johannes Winkler
, Ernst Urban
, Christian Noe (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

A synthesis of the amino sugar 2-amino-2,3-didesoxyribose is described. Starting from D-glucosamine, ß-methylfuranoside was obtained in eight steps in 20% yield. This carbohydrate is a novel building block for nucleosides and for backbone modified antisense oligonucleotides with 2'-5' amide linkages.

Original language	English
Pages (from-to)	109-116
Number of pages	8
Journal	Monatshefte für Chemie
Volume	135
Issue number	1
DOIs	https://doi.org/10.1007/s00706-003-0086-1 https://doi.org/10.1007/s00706-003-0086-1
Publication status	Published - 2004

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry
104015 Organic chemistry
304003 Genetic engineering

Keywords

Amino sugar
Carbohydrates
Oligonucleotides
Ribose derivatives

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title = "{\ss}-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides",

abstract = "A synthesis of the amino sugar 2-amino-2,3-didesoxyribose is described. Starting from D-glucosamine, {\ss}-methylfuranoside was obtained in eight steps in 20\% yield. This carbohydrate is a novel building block for nucleosides and for backbone modified antisense oligonucleotides with 2'-5' amide linkages.",

keywords = "Amino sugar, Carbohydrates, Oligonucleotides, Ribose derivatives",

author = "Johannes Winkler and Ernst Urban and Christian Noe",

year = "2004",

doi = "10.1007/s00706-003-0086-1",

language = "English",

volume = "135",

pages = "109--116",

journal = "Monatshefte f{\"u}r Chemie",

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TY - JOUR

T1 - ß-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides

AU - Winkler, Johannes

AU - Urban, Ernst

AU - Noe, Christian

PY - 2004

Y1 - 2004

N2 - A synthesis of the amino sugar 2-amino-2,3-didesoxyribose is described. Starting from D-glucosamine, ß-methylfuranoside was obtained in eight steps in 20% yield. This carbohydrate is a novel building block for nucleosides and for backbone modified antisense oligonucleotides with 2'-5' amide linkages.

AB - A synthesis of the amino sugar 2-amino-2,3-didesoxyribose is described. Starting from D-glucosamine, ß-methylfuranoside was obtained in eight steps in 20% yield. This carbohydrate is a novel building block for nucleosides and for backbone modified antisense oligonucleotides with 2'-5' amide linkages.

KW - Amino sugar

KW - Carbohydrates

KW - Oligonucleotides

KW - Ribose derivatives

UR - https://www.scopus.com/pages/publications/0842306844

U2 - 10.1007/s00706-003-0086-1

DO - 10.1007/s00706-003-0086-1

M3 - Article

SN - 0026-9247

VL - 135

SP - 109

EP - 116

JO - Monatshefte für Chemie

JF - Monatshefte für Chemie

IS - 1

ER -

ß-Methyl-2-amino-2,3-didesoxyribofuranoside, a Novel Building Block for Backbone Modified Antisense Oligonucleotides

Abstract

Austrian Fields of Science 2012

Keywords

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