1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity

Lisa-Maria Recnik; Wolfgang Kandioller; Thomas L. Mindt

doi:10.3390/molecules25163576

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity

Lisa-Maria Recnik
, Wolfgang Kandioller
, Thomas L. Mindt (Corresponding author)

Department of Inorganic Chemistry

Publications: Contribution to journal › Review › Peer Reviewed

Original language	English
Article number	3576
Number of pages	26
Journal	Molecules
Volume	25
Issue number	16
DOIs	https://doi.org/10.3390/molecules25163576
Publication status	Published - Aug 2020

Funding

We thank the Austrian Science Fund FWF for funding (Project Nr. P 31477-B28 to WK and TLM).

Austrian Fields of Science 2012

106002 Biochemistry
106023 Molecular biology

Keywords

1
4-disubstituted 1
2
3-triazoles
CuAAC
peptidomimetics
amide bond surrogate
metabolic stabilisation
CLICK CHEMISTRY
AMINO-ACIDS
SOLID-PHASE
BIOACTIVE CONFORMATION
BACKBONE FUNCTION
DRUG DISCOVERY
RECEPTOR
TRIAZOLE
ANALOGS
DESIGN
Peptidomimetics
Metabolic stabilisation
1,4-Disubstituted 1,2,3-triazoles
Amide bond surrogate

Access to Document

10.3390/molecules25163576Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1248451Licence: CC BY 4.0

Cite this

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title = "1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity",

keywords = "1, 4-disubstituted 1, 2, 3-triazoles, CuAAC, peptidomimetics, amide bond surrogate, metabolic stabilisation, CLICK CHEMISTRY, AMINO-ACIDS, SOLID-PHASE, BIOACTIVE CONFORMATION, BACKBONE FUNCTION, DRUG DISCOVERY, RECEPTOR, TRIAZOLE, ANALOGS, DESIGN, Peptidomimetics, Metabolic stabilisation, 1,4-Disubstituted 1,2,3-triazoles, Amide bond surrogate",

author = "Lisa-Maria Recnik and Wolfgang Kandioller and Mindt, \{Thomas L.\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors.",

year = "2020",

month = aug,

doi = "10.3390/molecules25163576",

language = "English",

volume = "25",

journal = "Molecules",

issn = "1420-3049",

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TY - JOUR

T1 - 1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity

AU - Recnik, Lisa-Maria

AU - Kandioller, Wolfgang

AU - Mindt, Thomas L.

PY - 2020/8

Y1 - 2020/8

KW - 1

KW - 4-disubstituted 1

KW - 2

KW - 3-triazoles

KW - CuAAC

KW - peptidomimetics

KW - amide bond surrogate

KW - metabolic stabilisation

KW - CLICK CHEMISTRY

KW - AMINO-ACIDS

KW - SOLID-PHASE

KW - BIOACTIVE CONFORMATION

KW - BACKBONE FUNCTION

KW - DRUG DISCOVERY

KW - RECEPTOR

KW - TRIAZOLE

KW - ANALOGS

KW - DESIGN

KW - Peptidomimetics

KW - Metabolic stabilisation

KW - 1,4-Disubstituted 1,2,3-triazoles

KW - Amide bond surrogate

UR - https://www.scopus.com/pages/publications/85089360082

U2 - 10.3390/molecules25163576

DO - 10.3390/molecules25163576

M3 - Review

SN - 1420-3049

VL - 25

JO - Molecules

JF - Molecules

IS - 16

M1 - 3576

ER -

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity

Funding

Austrian Fields of Science 2012

Keywords

Access to Document

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