Abstract
Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and TEAD is an interesting target for cancer therapy. The TEAD binding domain of YAP was mapped to protein residues 50–171. To obtain further structural insights into this 12 kDa segment of YAP, we report a backbone and a partial sidechain assignment of recombinant YAP 50–171.
Original language | English |
---|---|
Pages (from-to) | 179-182 |
Number of pages | 4 |
Journal | Biomolecular NMR Assignments |
Volume | 12 |
Issue number | 1 |
DOIs | |
Publication status | Published - Apr 2018 |
Austrian Fields of Science 2012
- 106041 Structural biology
Keywords
- CANCER
- HIPPO PATHWAY
- Hippo pathway
- Intrinsically disordered protein
- NMR
- TEAD
- TRANSCRIPTION FACTORS
- YAP