1H, 13C, 15N resonance assignment of human YAP 50–171 fragment

Michael Feichtinger, Tomas Sara, Gerald Platzer, Borja Mateos, Fedir Bokhovchuk, Patrick Chène, Robert Konrat

Publications: Contribution to journalArticlePeer Reviewed

Abstract

Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and TEAD is an interesting target for cancer therapy. The TEAD binding domain of YAP was mapped to protein residues 50–171. To obtain further structural insights into this 12 kDa segment of YAP, we report a backbone and a partial sidechain assignment of recombinant YAP 50–171.
Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalBiomolecular NMR Assignments
Volume12
Issue number1
DOIs
Publication statusPublished - Apr 2018

Austrian Fields of Science 2012

  • 106041 Structural biology

Keywords

  • CANCER
  • HIPPO PATHWAY
  • Hippo pathway
  • Intrinsically disordered protein
  • NMR
  • TEAD
  • TRANSCRIPTION FACTORS
  • YAP

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