A mathematical framework for yield (vs. rate) optimization in constraint-based modeling and applications in metabolic engineering

Steffen Klamt, Stefan Müller, Georg Regensburger, Juergen Zanghellini

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)153-169
Number of pages17
JournalMetabolic engineering
Volume47
DOIs
Publication statusPublished - 2018

Austrian Fields of Science 2012

  • 101004 Biomathematics

Keywords

  • Constraint-based modeling
  • Elementary flux mode
  • Elementary flux vector
  • Flux-balance analysis
  • Linear-fractional program
  • Metabolic pathway analysis
  • Production envelope
  • Productivity
  • Strain design
  • Yield space
  • MINIMAL CUT SETS
  • ELEMENTARY FLUX MODES
  • STRAIN OPTIMIZATION
  • KNOCKOUT STRATEGIES
  • PATHWAY ANALYSIS
  • BALANCE ANALYSIS
  • NETWORKS
  • CELLNETANALYZER
  • OVERPRODUCTION
  • CELL

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