A method for the synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans

Danilo Annibali, Gerhard Ecker, Wilhelm Fleischhacker, Thomas Helml, Wolfgang Holzer, Christian Noe

    Publications: Contribution to journalArticlePeer Reviewed

    Abstract

    The synthesis of 2,3-disubstituted 2,3-dihydrobenzofuran diastereomers is described. The key step in the reaction sequence is the chemoselective reduction of a tert. alcohole with tert.-butylamine-borane/AICl3. The relative configuration of the substituents on the dihydrofurane moiety was assigned via NMR spectroscopy.
    Original languageEnglish
    Pages (from-to)375-382
    Number of pages8
    JournalMonatshefte für Chemie
    Volume131
    Issue number4
    DOIs
    Publication statusPublished - 2000

    Austrian Fields of Science 2012

    • 3012 Pharmacy, Pharmacology, Toxicology

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