A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Stefan Reich; Chi D. L. Nguyen; Canan Has; Sascha Steltgens; Himanshu Soni; Cristina Coman; Moritz Freyberg; Anna Bichler; Nicole Seifert; Dominik Conrad; Christiane B. Knobbe-Thomsen; Bjoern Tews; Grischa Toedt; Robert Ahrends; Jan Medenbach

doi:10.1038/s41467-020-16747-y

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Bjoern Tews, Grischa Toedt, Robert Ahrends (Corresponding author), Jan Medenbach (Corresponding author)

Department of Analytical Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	2936
Number of pages	15
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-16747-y
Publication status	Published - 10 Jun 2020

Austrian Fields of Science 2012

106002 Biochemistry
106037 Proteomics
104002 Analytical chemistry

Keywords

ENDOPLASMIC-RETICULUM STRESS
MESSENGER-RNA TRANSLATION
MITOCHONDRIAL FOLATE
THERAPEUTIC TARGET
PATHWAY
SERINE
CANCER
EXPRESSION
REGULATOR
PROMOTES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-020-16747-yLicence: CC BY 4.0

https://phaidra.univie.ac.at/o:1373860Licence: CC BY 4.0

Cite this

Reich, S., Nguyen, C. D. L., Has, C., Steltgens, S., Soni, H., Coman, C., Freyberg, M., Bichler, A., Seifert, N., Conrad, D., Knobbe-Thomsen, C. B., Tews, B., Toedt, G., Ahrends, R., & Medenbach, J. (2020). A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites. Nature Communications, 11(1), Article 2936. https://doi.org/10.1038/s41467-020-16747-y

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title = "A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites",

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author = "Stefan Reich and Nguyen, {Chi D. L.} and Canan Has and Sascha Steltgens and Himanshu Soni and Cristina Coman and Moritz Freyberg and Anna Bichler and Nicole Seifert and Dominik Conrad and Knobbe-Thomsen, {Christiane B.} and Bjoern Tews and Grischa Toedt and Robert Ahrends and Jan Medenbach",

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doi = "10.1038/s41467-020-16747-y",

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Reich, S, Nguyen, CDL, Has, C, Steltgens, S, Soni, H, Coman, C, Freyberg, M, Bichler, A, Seifert, N, Conrad, D, Knobbe-Thomsen, CB, Tews, B, Toedt, G, Ahrends, R & Medenbach, J 2020, 'A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites', Nature Communications, vol. 11, no. 1, 2936. https://doi.org/10.1038/s41467-020-16747-y

TY - JOUR

T1 - A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

AU - Reich, Stefan

AU - Nguyen, Chi D. L.

AU - Has, Canan

AU - Steltgens, Sascha

AU - Soni, Himanshu

AU - Coman, Cristina

AU - Freyberg, Moritz

AU - Bichler, Anna

AU - Seifert, Nicole

AU - Conrad, Dominik

AU - Knobbe-Thomsen, Christiane B.

AU - Tews, Bjoern

AU - Toedt, Grischa

AU - Ahrends, Robert

AU - Medenbach, Jan

PY - 2020/6/10

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KW - MESSENGER-RNA TRANSLATION

KW - MITOCHONDRIAL FOLATE

KW - THERAPEUTIC TARGET

KW - PATHWAY

KW - SERINE

KW - CANCER

KW - EXPRESSION

KW - REGULATOR

KW - PROMOTES

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U2 - 10.1038/s41467-020-16747-y

DO - 10.1038/s41467-020-16747-y

M3 - Article

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 2936

ER -

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

Austrian Fields of Science 2012

Keywords

UN SDGs

Access to Document

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