A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

Karem Shanab; Catharina Neudorfer; Wolfgang Holzer; Markus Mitterhauser; Wolfgang Wadsak; Helmut Spreitzer

doi:10.3390/molecules19044076

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

Karem Shanab (Corresponding author), Catharina Neudorfer, Wolfgang Holzer, Markus Mitterhauser, Wolfgang Wadsak, Helmut Spreitzer

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethylsulfanyl) carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2-8 in a single step.

Original language	English
Pages (from-to)	4076-4082
Number of pages	7
Journal	Molecules
Volume	19
Issue number	4
DOIs	https://doi.org/10.3390/molecules19044076
Publication status	Published - Apr 2014

Austrian Fields of Science 2012

104015 Organic chemistry
301207 Pharmaceutical chemistry
301305 Medical chemistry

Keywords

chemoselective
alkylation
microwave
adenosine A3
PET
radiotracer
RECEPTOR
TARGET
Adenosine A3
Microwave
Radiotracer
Alkylation
Chemoselective

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10.3390/molecules19044076Licence: CC BY 3.0

http://phaidra.univie.ac.at/o:467248Licence: CC BY 3.0

Cite this

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abstract = "The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethylsulfanyl) carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2-8 in a single step.",

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AU - Neudorfer, Catharina

AU - Holzer, Wolfgang

AU - Mitterhauser, Markus

AU - Wadsak, Wolfgang

AU - Spreitzer, Helmut

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KW - alkylation

KW - microwave

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KW - PET

KW - radiotracer

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A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

Abstract

Austrian Fields of Science 2012

Keywords

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