A selectivity filter mutation provides insights into gating regulation of a K+ channel

Theres Friesacher; Haritha P. Reddy; Harald Bernsteiner; J. Carlo Combista; Boris Shalomov; Amal K. Bera; Eva Maria Zangerl-Plessl; Nathan Dascal; Anna Stary-Weinzinger

doi:10.1038/s42003-022-03303-1

A selectivity filter mutation provides insights into gating regulation of a K⁺ channel

Theres Friesacher
, Haritha P. Reddy
, Harald Bernsteiner
, J. Carlo Combista
, Boris Shalomov
, Amal K. Bera
, Eva Maria Zangerl-Plessl
, Nathan Dascal
, Anna Stary-Weinzinger

Department of Pharmaceutical Sciences

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	345
Number of pages	13
Journal	Communications Biology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/s42003-022-03303-1
Publication status	Published - 11 Apr 2022

Funding

The computational results presented have been achieved in part using the Vienna Scientific Cluster (VSC). This work was supported by the doctoral program “Molecular drug targets” W1232 (T.F. and A.S.-W.) and the Post-Doc program “Zukunftskolleg” ZK-81B of the Austrian Science Fund (FWF) (T.F. and E.-M. Z.-P.), the DOC fellowship 26156 of the Austrian Academy of Sciences (ÖAW) (T.F.), the Israel-India Binational grant (Israeli # ISF_2255_2015 and Indian # UGC-6-1/2016 (1C) (N.D. and A.K.B); Israel Science Foundation grant # ISF_1282_2018 (N.D.). The computational results presented have been achieved in part using the Vienna Scientific Cluster (VSC). This work was supported by the doctoral program ?Molecular drug targets? W1232 (T.F.?and A.S.-W.) and the Post-Doc program ?Zukunftskolleg? ZK-81B of the Austrian Science Fund (FWF) (T.F. and E.-M. Z.-P.), the DOC fellowship 26156 of the Austrian Academy of Sciences (?AW) (T.F.), the Israel-India Binational grant (Israeli # ISF_2255_2015 and Indian # UGC-6-1/2016 (1C) (N.D. and A.K.B); Israel Science Foundation grant # ISF_1282_2018 (N.D.).

Austrian Fields of Science 2012

301206 Pharmacology

Keywords

G-BETA-GAMMA
POTASSIUM-CHANNEL
WEAVER MUTATION
CEREBELLAR CORTEX
STRUCTURAL BASIS
BASAL ACTIVITY
GIRK CHANNELS
GRANULE CELLS
ION-BINDING
G-PROTEINS

Access to Document

10.1038/s42003-022-03303-1Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1681154Licence: CC BY 4.0

Cite this

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title = "A selectivity filter mutation provides insights into gating regulation of a K+ channel",

keywords = "G-BETA-GAMMA, POTASSIUM-CHANNEL, WEAVER MUTATION, CEREBELLAR CORTEX, STRUCTURAL BASIS, BASAL ACTIVITY, GIRK CHANNELS, GRANULE CELLS, ION-BINDING, G-PROTEINS",

author = "Theres Friesacher and Reddy, \{Haritha P.\} and Harald Bernsteiner and \{Carlo Combista\}, J. and Boris Shalomov and Bera, \{Amal K.\} and Zangerl-Plessl, \{Eva Maria\} and Nathan Dascal and Anna Stary-Weinzinger",

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doi = "10.1038/s42003-022-03303-1",

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T1 - A selectivity filter mutation provides insights into gating regulation of a K+ channel

AU - Friesacher, Theres

AU - Reddy, Haritha P.

AU - Bernsteiner, Harald

AU - Carlo Combista, J.

AU - Shalomov, Boris

AU - Bera, Amal K.

AU - Zangerl-Plessl, Eva Maria

AU - Dascal, Nathan

AU - Stary-Weinzinger, Anna

PY - 2022/4/11

Y1 - 2022/4/11

KW - G-BETA-GAMMA

KW - POTASSIUM-CHANNEL

KW - WEAVER MUTATION

KW - CEREBELLAR CORTEX

KW - STRUCTURAL BASIS

KW - BASAL ACTIVITY

KW - GIRK CHANNELS

KW - GRANULE CELLS

KW - ION-BINDING

KW - G-PROTEINS

UR - https://www.scopus.com/pages/publications/85128061947

U2 - 10.1038/s42003-022-03303-1

DO - 10.1038/s42003-022-03303-1

M3 - Article

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AN - SCOPUS:85128061947

SN - 2399-3642

VL - 5

JO - Communications Biology

JF - Communications Biology

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ER -