Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Lian-Wu Xie; Atanas G Atanasov; De-An Guo; Clemens Malainer; Jing-Xian Zhang; Martin Zehl; Shu-Hong Guan; Elke H Heiss; Ernst Urban; Verena M Dirsch; Brigitte Kopp

doi:10.1016/j.jep.2014.01.029

Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Lian-Wu Xie
, Atanas G Atanasov
, De-An Guo
, Clemens Malainer
, Jing-Xian Zhang
, Martin Zehl
, Shu-Hong Guan
, Elke H Heiss
, Ernst Urban
, Verena M Dirsch
, Brigitte Kopp

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	470-477
Number of pages	8
Journal	Journal of Ethnopharmacology
Volume	152
Issue number	3
DOIs	https://doi.org/10.1016/j.jep.2014.01.029
Publication status	Published - 28 Mar 2014

Funding

The authors thank Prof. Ronald M. Evans for providing the PPRE luciferase reporter construct, Prof. Walter Wahli and Prof. Beatrice Desvergne for sharing the plasmid encoding human PPAR gamma. We gratefully acknowledge the expert technical assistance of E. Geiger, J. Benedics, and M. Gossinger. This research was supported by the Sino-Austria Project (China-TCM-Cluster Project PP06), the China Postdoctoral Science Foundation Funded Project (2013M531787), and was partially funded by the Planned Science and Technology Project of Hunan Province, China (2013RS4035) and by the Austrian Science Fund (FWF): S10704 (NFN Drugs from Nature Targeting Inflammation (DNTI)).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry
301204 Pharmacognosy

Keywords

Fatty acids
Lycii Radicis Cortex
Lycium chinense Miller
NF-κB
Phenolic amides
PPARγ

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10.1016/j.jep.2014.01.029

Cite this

@article{f87bf54e6a7744478eb5f17e88558ba2,

title = "Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller",

keywords = "Fatty acids, Lycii Radicis Cortex, Lycium chinense Miller, NF-κB, Phenolic amides, PPARγ",

author = "Lian-Wu Xie and Atanasov, \{Atanas G\} and De-An Guo and Clemens Malainer and Jing-Xian Zhang and Martin Zehl and Shu-Hong Guan and Heiss, \{Elke H\} and Ernst Urban and Dirsch, \{Verena M\} and Brigitte Kopp",

note = "Funding Information: The authors thank Prof. Ronald M. Evans for providing the PPRE luciferase reporter construct, Prof. Walter Wahli and Prof. Beatrice Desvergne for sharing the plasmid encoding human PPARγ. We gratefully acknowledge the expert technical assistance of E. Geiger, J. Benedics, and M. G{\"o}ssinger. This research was supported by the Sino-Austria Project (China-TCM-Cluster Project PP06), the China Postdoctoral Science Foundation Funded Project ( 2013M531787 ), and was partially funded by the Planned Science and Technology Project of Hunan Province, China ( 2013RS4035 ) and by the Austrian Science Fund (FWF) : S10704 (NFN Drugs from Nature Targeting Inflammation (DNTI)).",

year = "2014",

month = mar,

day = "28",

doi = "10.1016/j.jep.2014.01.029",

language = "English",

volume = "152",

pages = "470--477",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

number = "3",

}

TY - JOUR

T1 - Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

AU - Xie, Lian-Wu

AU - Atanasov, Atanas G

AU - Guo, De-An

AU - Malainer, Clemens

AU - Zhang, Jing-Xian

AU - Zehl, Martin

AU - Guan, Shu-Hong

AU - Heiss, Elke H

AU - Urban, Ernst

AU - Dirsch, Verena M

AU - Kopp, Brigitte

N1 - Funding Information: The authors thank Prof. Ronald M. Evans for providing the PPRE luciferase reporter construct, Prof. Walter Wahli and Prof. Beatrice Desvergne for sharing the plasmid encoding human PPARγ. We gratefully acknowledge the expert technical assistance of E. Geiger, J. Benedics, and M. Gössinger. This research was supported by the Sino-Austria Project (China-TCM-Cluster Project PP06), the China Postdoctoral Science Foundation Funded Project ( 2013M531787 ), and was partially funded by the Planned Science and Technology Project of Hunan Province, China ( 2013RS4035 ) and by the Austrian Science Fund (FWF) : S10704 (NFN Drugs from Nature Targeting Inflammation (DNTI)).

PY - 2014/3/28

Y1 - 2014/3/28

KW - Fatty acids

KW - Lycii Radicis Cortex

KW - Lycium chinense Miller

KW - NF-κB

KW - Phenolic amides

KW - PPARγ

UR - https://www.scopus.com/pages/publications/84900359212

U2 - 10.1016/j.jep.2014.01.029

DO - 10.1016/j.jep.2014.01.029

M3 - Article

C2 - 24512737

SN - 0378-8741

VL - 152

SP - 470

EP - 477

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 3

ER -

Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

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