Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Dominik Loser; Karin Grillberger; Maria G Hinojosa; Jonathan Blum; Yves Haufe; Timm Danker; Ylva Johansson; Clemens Möller; Annette Nicke; Susanne H Bennekou; Iain Gardner; Caroline Bauch; Paul Walker; Anna Forsby; Gerhard F Ecker; Udo Kraushaar; Marcel Leist

doi:10.1007/s00204-021-03168-z

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

Dominik Loser
, Karin Grillberger
, Maria G Hinojosa
, Jonathan Blum
, Yves Haufe
, Timm Danker
, Ylva Johansson
, Clemens Möller
, Annette Nicke
, Susanne H Bennekou
, Iain Gardner
, Caroline Bauch
, Paul Walker
, Anna Forsby
, Gerhard F Ecker
, Udo Kraushaar
, Marcel Leist

Department of Pharmaceutical Sciences

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	3695-3716
Number of pages	22
Journal	Archives of Toxicology
Volume	95
Issue number	12
DOIs	https://doi.org/10.1007/s00204-021-03168-z
Publication status	Published - 10 Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301211 Toxicology

Keywords

ACH BINDING-SITE
ALDEHYDE OXIDASE
DEVELOPMENTAL NEUROTOXICITY
Developmental neurotoxicity
HUMAN ALPHA-4-BETA-2
IN-VITRO
LONG-TERM EXPOSURE
Live-cell calcium imaging
Molecular docking
NEONICOTINOID INSECTICIDES
NICOTINIC ACETYLCHOLINE-RECEPTORS
Nicotine
Oocyte recording
POSITIVE ALLOSTERIC MODULATOR
Pesticide metabolism
SYNAPTIC-TRANSMISSION

Access to Document

10.1007/s00204-021-03168-z

Cite this

Loser, D., Grillberger, K., Hinojosa, M. G., Blum, J., Haufe, Y., Danker, T., Johansson, Y., Möller, C., Nicke, A., Bennekou, S. H., Gardner, I., Bauch, C., Walker, P., Forsby, A., Ecker, G. F., Kraushaar, U., & Leist, M. (2021). Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling. Archives of Toxicology, 95(12), 3695-3716. https://doi.org/10.1007/s00204-021-03168-z

@article{b3984bae78054b0783736bb8727133d1,

title = "Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling",

keywords = "ACH BINDING-SITE, ALDEHYDE OXIDASE, DEVELOPMENTAL NEUROTOXICITY, Developmental neurotoxicity, HUMAN ALPHA-4-BETA-2, IN-VITRO, LONG-TERM EXPOSURE, Live-cell calcium imaging, Molecular docking, NEONICOTINOID INSECTICIDES, NICOTINIC ACETYLCHOLINE-RECEPTORS, Nicotine, Oocyte recording, POSITIVE ALLOSTERIC MODULATOR, Pesticide metabolism, SYNAPTIC-TRANSMISSION",

author = "Dominik Loser and Karin Grillberger and Hinojosa, \{Maria G\} and Jonathan Blum and Yves Haufe and Timm Danker and Ylva Johansson and Clemens M{\"o}ller and Annette Nicke and Bennekou, \{Susanne H\} and Iain Gardner and Caroline Bauch and Paul Walker and Anna Forsby and Ecker, \{Gerhard F\} and Udo Kraushaar and Marcel Leist",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = oct,

day = "10",

doi = "10.1007/s00204-021-03168-z",

language = "English",

volume = "95",

pages = "3695--3716",

journal = "Archives of Toxicology",

issn = "0340-5761",

publisher = "Springer-Verlag Berlin-Heidelberg",

number = "12",

}

Loser, D, Grillberger, K, Hinojosa, MG, Blum, J, Haufe, Y, Danker, T, Johansson, Y, Möller, C, Nicke, A, Bennekou, SH, Gardner, I, Bauch, C, Walker, P, Forsby, A, Ecker, GF, Kraushaar, U & Leist, M 2021, 'Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling', Archives of Toxicology, vol. 95, no. 12, pp. 3695-3716. https://doi.org/10.1007/s00204-021-03168-z

TY - JOUR

T1 - Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

AU - Loser, Dominik

AU - Grillberger, Karin

AU - Hinojosa, Maria G

AU - Blum, Jonathan

AU - Haufe, Yves

AU - Danker, Timm

AU - Johansson, Ylva

AU - Möller, Clemens

AU - Nicke, Annette

AU - Bennekou, Susanne H

AU - Gardner, Iain

AU - Bauch, Caroline

AU - Walker, Paul

AU - Forsby, Anna

AU - Ecker, Gerhard F

AU - Kraushaar, Udo

AU - Leist, Marcel

PY - 2021/10/10

Y1 - 2021/10/10

KW - ACH BINDING-SITE

KW - ALDEHYDE OXIDASE

KW - DEVELOPMENTAL NEUROTOXICITY

KW - Developmental neurotoxicity

KW - HUMAN ALPHA-4-BETA-2

KW - IN-VITRO

KW - LONG-TERM EXPOSURE

KW - Live-cell calcium imaging

KW - Molecular docking

KW - NEONICOTINOID INSECTICIDES

KW - NICOTINIC ACETYLCHOLINE-RECEPTORS

KW - Nicotine

KW - Oocyte recording

KW - POSITIVE ALLOSTERIC MODULATOR

KW - Pesticide metabolism

KW - SYNAPTIC-TRANSMISSION

UR - https://www.scopus.com/pages/publications/85116827017

U2 - 10.1007/s00204-021-03168-z

DO - 10.1007/s00204-021-03168-z

M3 - Article

C2 - 34628512

SN - 0340-5761

VL - 95

SP - 3695

EP - 3716

JO - Archives of Toxicology

JF - Archives of Toxicology

IS - 12

ER -

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

Other files and links

Fingerprint

EU-ToxRisk: EU-ToxRisk

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Cite this

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

Other files and links

Fingerprint

Projects

EU-ToxRisk: EU-ToxRisk

Research output

Structural Insights into Neonicotinoids and N-Unsubstituted Metabolites on Human nAChRs by Molecular Docking, Dynamics Simulations, and Calcium Imaging

Cite this