Aluminum-Substituted Keggin Germanotungstate [HARH(2)O)GeW11O39](4-): Synthesis, Characterization, and Antibacterial Activity

Elias Tanuhadi; Nadiia Gumerova; Alexander Prado-Roller; Mathea Sophia Galanski; Hana Cipcic-Paljetak; Donatella Verbanac; Annette Rompel

doi:10.1021/acs.inorgchem.0c03311

Aluminum-Substituted Keggin Germanotungstate [HARH(2)O)GeW11O39](4-): Synthesis, Characterization, and Antibacterial Activity

Elias Tanuhadi
, Nadiia Gumerova
, Alexander Prado-Roller
, Mathea Sophia Galanski
, Hana Cipcic-Paljetak
, Donatella Verbanac
, Annette Rompel (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

We report on the new monosubstituted aluminum Keggin-type germanotungstate (C4H12N)(4)[HAIGeW(11)O(39)(H2O)]center dot 11H(2)O GAI(H2O)GeW11](4-)), which has been synthesized at room temperature via rearrangement of the dilacunary [gamma-GeW10O36](8-) polyoxometalate precursor. [Al(H2O)GeW11](4-) has been characterized thoroughly both in the solid state by single-crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis as well as in solution by cyclic voltammetry (CV) W-183, Al-27 NMR and UV-vis spectroscopy. A study on the antibacterial properties of [Al(H2O)GeW11](4-) and the known aluminum(III)-centered Keggin polyoxotungstates (Al-POTs) alpha-Na-5[AlW12O40] (alpha-[AlW12O40](5-)) and Na-6[Al(AlOH2)W11O39] ([Al(AIOH(2))W11O39](6-)) revealed enhanced activity for all three Al-POTs against the Gram-negative bacterium Moraxella catarrhalis (minimum inhibitory concentration (MIC) up to 4 mu g mL(-1)) and the Gram-positive Enterococcus faecalis (MIC up to 128 mu g mL(-1)) compared to the inactive Al(NO3)(3) salt (MIC > 256 mu g mL(-1)). CV indicates the redox activity of the Al-POTs as a dominating factor for the observed antibacterial activity with increased tendency to reduction, resulting in increased antibacterial activity of the POT.

Original language	English
Pages (from-to)	28-31
Number of pages	4
Journal	Inorganic Chemistry
Volume	60
Issue number	1
DOIs	https://doi.org/10.1021/acs.inorgchem.0c03311
Publication status	Published - 4 Jan 2021

Funding

We gratefully acknowledge the Austrian Science Fund FWF (Grants P27534, P33089, M2203, and P33927) as well as the University of Vienna for financial support. E.T. and A.R. acknowledge the University of Vienna for awarding a Uni:docs fellowship to E.T. Bilateral financial funding was provided by the Centre for International Cooperation & Mobility (ICM) of the Austrian Agency for International Cooperation in Education and Research (OeADGmbH) Project HR 06/2020 to A.R. and the Project "Biological profiling of polyoxometalates" to H.C.-P. Last, the authors thank Heiko Geisler, M.Sc., for assistance with CV measurements, Marek Bujdos for support with ICP-OES measurements, and Ass. Prof. Dr. Peter Unfried for TGA measurements.

Austrian Fields of Science 2012

104003 Inorganic chemistry

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10.1021/acs.inorgchem.0c03311

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title = "Aluminum-Substituted Keggin Germanotungstate [HARH(2)O)GeW11O39](4-): Synthesis, Characterization, and Antibacterial Activity",

abstract = "We report on the new monosubstituted aluminum Keggin-type germanotungstate (C4H12N)(4)[HAIGeW(11)O(39)(H2O)]center dot 11H(2)O GAI(H2O)GeW11](4-)), which has been synthesized at room temperature via rearrangement of the dilacunary [gamma-GeW10O36](8-) polyoxometalate precursor. [Al(H2O)GeW11](4-) has been characterized thoroughly both in the solid state by single-crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis as well as in solution by cyclic voltammetry (CV) W-183, Al-27 NMR and UV-vis spectroscopy. A study on the antibacterial properties of [Al(H2O)GeW11](4-) and the known aluminum(III)-centered Keggin polyoxotungstates (Al-POTs) alpha-Na-5[AlW12O40] (alpha-[AlW12O40](5-)) and Na-6[Al(AlOH2)W11O39] ([Al(AIOH(2))W11O39](6-)) revealed enhanced activity for all three Al-POTs against the Gram-negative bacterium Moraxella catarrhalis (minimum inhibitory concentration (MIC) up to 4 mu g mL(-1)) and the Gram-positive Enterococcus faecalis (MIC up to 128 mu g mL(-1)) compared to the inactive Al(NO3)(3) salt (MIC > 256 mu g mL(-1)). CV indicates the redox activity of the Al-POTs as a dominating factor for the observed antibacterial activity with increased tendency to reduction, resulting in increased antibacterial activity of the POT.",

author = "Elias Tanuhadi and Nadiia Gumerova and Alexander Prado-Roller and Galanski, \{Mathea Sophia\} and Hana Cipcic-Paljetak and Donatella Verbanac and Annette Rompel",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

year = "2021",

month = jan,

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doi = "10.1021/acs.inorgchem.0c03311",

language = "English",

volume = "60",

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journal = "Inorganic Chemistry",

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T1 - Aluminum-Substituted Keggin Germanotungstate [HARH(2)O)GeW11O39](4-): Synthesis, Characterization, and Antibacterial Activity

AU - Tanuhadi, Elias

AU - Gumerova, Nadiia

AU - Prado-Roller, Alexander

AU - Galanski, Mathea Sophia

AU - Cipcic-Paljetak, Hana

AU - Verbanac, Donatella

AU - Rompel, Annette

PY - 2021/1/4

Y1 - 2021/1/4

N2 - We report on the new monosubstituted aluminum Keggin-type germanotungstate (C4H12N)(4)[HAIGeW(11)O(39)(H2O)]center dot 11H(2)O GAI(H2O)GeW11](4-)), which has been synthesized at room temperature via rearrangement of the dilacunary [gamma-GeW10O36](8-) polyoxometalate precursor. [Al(H2O)GeW11](4-) has been characterized thoroughly both in the solid state by single-crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis as well as in solution by cyclic voltammetry (CV) W-183, Al-27 NMR and UV-vis spectroscopy. A study on the antibacterial properties of [Al(H2O)GeW11](4-) and the known aluminum(III)-centered Keggin polyoxotungstates (Al-POTs) alpha-Na-5[AlW12O40] (alpha-[AlW12O40](5-)) and Na-6[Al(AlOH2)W11O39] ([Al(AIOH(2))W11O39](6-)) revealed enhanced activity for all three Al-POTs against the Gram-negative bacterium Moraxella catarrhalis (minimum inhibitory concentration (MIC) up to 4 mu g mL(-1)) and the Gram-positive Enterococcus faecalis (MIC up to 128 mu g mL(-1)) compared to the inactive Al(NO3)(3) salt (MIC > 256 mu g mL(-1)). CV indicates the redox activity of the Al-POTs as a dominating factor for the observed antibacterial activity with increased tendency to reduction, resulting in increased antibacterial activity of the POT.

AB - We report on the new monosubstituted aluminum Keggin-type germanotungstate (C4H12N)(4)[HAIGeW(11)O(39)(H2O)]center dot 11H(2)O GAI(H2O)GeW11](4-)), which has been synthesized at room temperature via rearrangement of the dilacunary [gamma-GeW10O36](8-) polyoxometalate precursor. [Al(H2O)GeW11](4-) has been characterized thoroughly both in the solid state by single-crystal and powder X-ray diffraction, IR spectroscopy, thermogravimetric analysis, and elemental analysis as well as in solution by cyclic voltammetry (CV) W-183, Al-27 NMR and UV-vis spectroscopy. A study on the antibacterial properties of [Al(H2O)GeW11](4-) and the known aluminum(III)-centered Keggin polyoxotungstates (Al-POTs) alpha-Na-5[AlW12O40] (alpha-[AlW12O40](5-)) and Na-6[Al(AlOH2)W11O39] ([Al(AIOH(2))W11O39](6-)) revealed enhanced activity for all three Al-POTs against the Gram-negative bacterium Moraxella catarrhalis (minimum inhibitory concentration (MIC) up to 4 mu g mL(-1)) and the Gram-positive Enterococcus faecalis (MIC up to 128 mu g mL(-1)) compared to the inactive Al(NO3)(3) salt (MIC > 256 mu g mL(-1)). CV indicates the redox activity of the Al-POTs as a dominating factor for the observed antibacterial activity with increased tendency to reduction, resulting in increased antibacterial activity of the POT.

UR - https://www.scopus.com/pages/publications/85098891675

U2 - 10.1021/acs.inorgchem.0c03311

DO - 10.1021/acs.inorgchem.0c03311

M3 - Article

SN - 0020-1669

VL - 60

SP - 28

EP - 31

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 1

ER -

Aluminum-Substituted Keggin Germanotungstate [HARH(2)O)GeW11O39](4-): Synthesis, Characterization, and Antibacterial Activity

Abstract

Funding

Austrian Fields of Science 2012

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