Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding

Carolin Fella; Greg F. Walker; Manfred Ogris; Ernst Wagner

doi:10.1016/j.ejps.2008.05.004

Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding

Carolin Fella
, Greg F. Walker
, Manfred Ogris
, Ernst Wagner

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	309-320
Number of pages	12
Journal	European Journal of Pharmaceutical Sciences
Volume	34
Issue number	4-5
DOIs	https://doi.org/10.1016/j.ejps.2008.05.004
Publication status	Published - 7 Aug 2008
Externally published	Yes

Funding

We thank Olga Bruck for skilful assistance in preparing the manuscript, and Daniel Honig and Hanna Engelke for help during the FCS experiments. This work was supported by EC funded project GIANT, DFG SFB486 and SPP1230, and the excellence cluster Nanosystems Initiative Munich (NIM).

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

bioreversible modification
drug delivery
gene transfer
PEGylation
PEG pyridylhydrazone NHS ester
plasmid DNA
TARGETED GENE DELIVERY
GLYCOL-POLYETHYLENIMINE/DNA COMPLEXES
PLASMID-LIPID PARTICLES
IN-VIVO
DNA COMPLEXES
LINEAR POLYETHYLENIMINE
INTRACELLULAR DELIVERY
STERIC STABILIZATION
EXTENDED CIRCULATION
SYNTHETIC VIRUSES

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10.1016/j.ejps.2008.05.004

Cite this

@article{5e06ab2da66145788db7d93ec9ef70f4,

title = "Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding",

keywords = "bioreversible modification, drug delivery, gene transfer, PEGylation, PEG pyridylhydrazone NHS ester, plasmid DNA, TARGETED GENE DELIVERY, GLYCOL-POLYETHYLENIMINE/DNA COMPLEXES, PLASMID-LIPID PARTICLES, IN-VIVO, DNA COMPLEXES, LINEAR POLYETHYLENIMINE, INTRACELLULAR DELIVERY, STERIC STABILIZATION, EXTENDED CIRCULATION, SYNTHETIC VIRUSES",

author = "Carolin Fella and Walker, \{Greg F.\} and Manfred Ogris and Ernst Wagner",

year = "2008",

month = aug,

day = "7",

doi = "10.1016/j.ejps.2008.05.004",

language = "English",

volume = "34",

pages = "309--320",

journal = "European Journal of Pharmaceutical Sciences",

issn = "0928-0987",

publisher = "Elsevier",

number = "4-5",

}

TY - JOUR

T1 - Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding

AU - Fella, Carolin

AU - Walker, Greg F.

AU - Ogris, Manfred

AU - Wagner, Ernst

PY - 2008/8/7

Y1 - 2008/8/7

KW - bioreversible modification

KW - drug delivery

KW - gene transfer

KW - PEGylation

KW - PEG pyridylhydrazone NHS ester

KW - plasmid DNA

KW - TARGETED GENE DELIVERY

KW - GLYCOL-POLYETHYLENIMINE/DNA COMPLEXES

KW - PLASMID-LIPID PARTICLES

KW - IN-VIVO

KW - DNA COMPLEXES

KW - LINEAR POLYETHYLENIMINE

KW - INTRACELLULAR DELIVERY

KW - STERIC STABILIZATION

KW - EXTENDED CIRCULATION

KW - SYNTHETIC VIRUSES

U2 - 10.1016/j.ejps.2008.05.004

DO - 10.1016/j.ejps.2008.05.004

M3 - Article

SN - 0928-0987

VL - 34

SP - 309

EP - 320

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 4-5

ER -

Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding

Funding

Austrian Fields of Science 2012

Keywords

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