An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity

Veronika Knorr; Manfred Ogris; Ernst Wagner

doi:10.1007/s11095-008-9700-6

An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity

Veronika Knorr
, Manfred Ogris
, Ernst Wagner

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	2937-2945
Number of pages	9
Journal	Pharmaceutical Research
Volume	25
Issue number	12
DOIs	https://doi.org/10.1007/s11095-008-9700-6
Publication status	Published - Dec 2008
Externally published	Yes

Funding

We thank Olga Bruck for skillful assistance in preparing the manuscript, as well as Wolfgang Roedl and Anna Kulinyak for competent technical assistance. This work was funded by the LMU university, by the DFG projects SFB 486 'Nanoman' and SPP1230, the Nanosystems Initiative Munich (NIM), and the European Community FP6 network project 'GIANT'.

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

gene transfer
ketal
nonviral
PEGylation
pH-sensitive
SYSTEMIC GENE DELIVERY
IN-VIVO
POLY(ETHYLENE GLYCOL)
BIOLOGICAL-PROPERTIES
HIGHLY EFFICIENT
DNA POLYPLEXES
POLYMER
VECTORS
COMPLEXES
CARRIERS

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title = "An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity",

keywords = "gene transfer, ketal, nonviral, PEGylation, pH-sensitive, SYSTEMIC GENE DELIVERY, IN-VIVO, POLY(ETHYLENE GLYCOL), BIOLOGICAL-PROPERTIES, HIGHLY EFFICIENT, DNA POLYPLEXES, POLYMER, VECTORS, COMPLEXES, CARRIERS",

author = "Veronika Knorr and Manfred Ogris and Ernst Wagner",

year = "2008",

month = dec,

doi = "10.1007/s11095-008-9700-6",

language = "English",

volume = "25",

pages = "2937--2945",

journal = "Pharmaceutical Research",

issn = "0724-8741",

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T1 - An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity

AU - Knorr, Veronika

AU - Ogris, Manfred

AU - Wagner, Ernst

PY - 2008/12

Y1 - 2008/12

KW - gene transfer

KW - ketal

KW - nonviral

KW - PEGylation

KW - pH-sensitive

KW - SYSTEMIC GENE DELIVERY

KW - IN-VIVO

KW - POLY(ETHYLENE GLYCOL)

KW - BIOLOGICAL-PROPERTIES

KW - HIGHLY EFFICIENT

KW - DNA POLYPLEXES

KW - POLYMER

KW - VECTORS

KW - COMPLEXES

KW - CARRIERS

U2 - 10.1007/s11095-008-9700-6

DO - 10.1007/s11095-008-9700-6

M3 - Article

SN - 0724-8741

VL - 25

SP - 2937

EP - 2945

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 12

ER -

An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity

Funding

Austrian Fields of Science 2012

Keywords

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