TY - JOUR
T1 - Antitumor effects of 3,3',4,4',5,5'-hexahydroxystilbene in HL-60 human promyelocytic leukemia cells
AU - Saiko, Philipp
AU - Horvath, Zsuzsanna
AU - Murias, Marek
AU - Handler, Norbert
AU - Jäger, Walter
AU - Erker, Thomas
AU - Fritzer-Szekeres, Monika
AU - Szekeres, Thomas
N1 - DOI: 10.1080/15257770600890624
Coden: NNNAF
Affiliations: Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria; Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria; Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Waehringer Guertel 18-20, A 1090 Vienna, Austria
Source-File: MedPharmChemScopus_iso.csv
Import aus Scopus: 2-s2.0-33750460283
Importdatum: 22.11.2006 17:15:28
09.08.2007: Datenanforderung 1815 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2006
Y1 - 2006
N2 - Resveratrol (3,4',5-trihydroxystilbene, RV) exerts remarkable cytostatic and cytotoxic effects against a multitude of human cancer cell lines. Since the introduction of additional hydroxyl groups was supposed to increase the biological activity of RV, we have synthesized a number of polyhydroxylated stilbene analogues as potential antitumor agents. In this study, the activity of 3,3',4,4',5,5'-hexahydroxystilbene (M8) was investigated in HL-60 human promyelocytic leukemia cells. Employing a growth inhibition assay, incubation with M8 and RV resulted in IC50 values of 6.25 and 12 œM, respectively. Using a specific Hoechst/propidium iodide double staining method, we found that M8 was able to induce apoptosis in concentrations significantly lower than those of RV. In addition, M8 arrested cells in the S phase and totally depleted cells in the G2-M phase of the cell cycle (143% and 0% of control after treatment with 12.5 œM M8, respectively). We therefore believe that this promising agent deserves further preclinical and in vivo testing. Copyright Œ Taylor & Francis Group, LLC.
AB - Resveratrol (3,4',5-trihydroxystilbene, RV) exerts remarkable cytostatic and cytotoxic effects against a multitude of human cancer cell lines. Since the introduction of additional hydroxyl groups was supposed to increase the biological activity of RV, we have synthesized a number of polyhydroxylated stilbene analogues as potential antitumor agents. In this study, the activity of 3,3',4,4',5,5'-hexahydroxystilbene (M8) was investigated in HL-60 human promyelocytic leukemia cells. Employing a growth inhibition assay, incubation with M8 and RV resulted in IC50 values of 6.25 and 12 œM, respectively. Using a specific Hoechst/propidium iodide double staining method, we found that M8 was able to induce apoptosis in concentrations significantly lower than those of RV. In addition, M8 arrested cells in the S phase and totally depleted cells in the G2-M phase of the cell cycle (143% and 0% of control after treatment with 12.5 œM M8, respectively). We therefore believe that this promising agent deserves further preclinical and in vivo testing. Copyright Œ Taylor & Francis Group, LLC.
U2 - 10.1080/15257770600890624
DO - 10.1080/15257770600890624
M3 - Article
SN - 1525-7770
VL - 25
SP - 1013
EP - 1017
JO - Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication
JF - Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication
IS - 9-11
ER -
