Appetite-Inducing Effects of Homoeriodictyol: Two Randomized, Cross-Over Interventions

Christina M. Hochkogler, Kathrin Liszt, Barbara Lieder, Verena Stoeger, Anna Stübler, Marc Pignitter, Joachim Hans, Sabine Widder, Jakob P. Ley, Gerhard E. Krammer, Veronika Somoza (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Abstract

Scope: Anorexia of aging, characterized by a decrease in appetite and/or food intake, is a major risk factor of under-nutrition and adverse health outcomes in elderly people. Recent in vitro evidence suggests homoeriodictyol (HED), a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. Methods and results: In two cross-over intervention trials, 30 mg NaHED, either solely (n = 10, Study I) or in combination with a 75 g glucose load (n = 17, study II) were administered to healthy adult subjects. Ratings of hunger were assessed at fasting and either 30 min (Study I) or 120 min (Study II) post intervention. Ad libitum energy intake from a standardized breakfast and plasma changes in hunger-/satiety-associated hormones PYY, GLP-1, ghrelin and serotonin were determined after blood drawings. Effects were more pronounced when NaHED was administered in combination with 75 g glucose since ad libitum energy (+ 9.52 ± 4.60%) and protein (+ 7.08 ± 7.97%) intake as well as plasma ΔAUC ghrelin values increased in study II solely, whereas plasma serotonin concentrations decreased after both interventions. Conclusions: NaHED demonstrated appetizing effects in healthy adults when administered with a glucose load. Long-term intervention studies are warranted to verify these effects in compromised subjects.

Original languageEnglish
Article number1700459
Number of pages9
JournalMolecular Nutrition & Food Research
Volume61
Issue number12
DOIs
Publication statusPublished - Dec 2017

Austrian Fields of Science 2012

  • 303009 Nutritional sciences

Keywords

  • appetizers
  • food intake
  • homoeriodictyol
  • peripheral serotonin
  • plasma ghrelin
  • PLASMA GHRELIN LEVELS
  • FOOD-INTAKE
  • OLDER-PEOPLE
  • MEGESTROL-ACETATE
  • BODY-WEIGHT
  • PEPTIDE-YY
  • SEROTONIN
  • ANOREXIA
  • IDENTIFICATION
  • GLUCOSE

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