Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Vanessa Schoissengeier; Lina Maqboul; Daniela Weber; Tilman Grune; Alexander Bürkle; Maria Moreno-Villaneuva; Claudio Franceschi; Miriam Capri; Jürgen Bernhard; Olivier Toussaint; Florence Debacq-Chainiaux; Birgit Weinberger; Efstathios S Gonos; Ewa Sikora; Martijn Dollé; Eugène Jansen; P Eline Slagboom; Antti Hervonnen; Mikko Hurme; Nicolle Breusing; Jan Frank; Andrew C Bulmer; Karl-Heinz Wagner

doi:10.1016/j.isci.2024.110234

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Vanessa Schoissengeier
, Lina Maqboul
, Daniela Weber
, Tilman Grune
, Alexander Bürkle
, Maria Moreno-Villaneuva
, Claudio Franceschi
, Miriam Capri
, Jürgen Bernhard
, Olivier Toussaint
, Florence Debacq-Chainiaux
, Birgit Weinberger
, Efstathios S Gonos
, Ewa Sikora
, Martijn Dollé
, Eugène Jansen
, P Eline Slagboom
, Antti Hervonnen
, Mikko Hurme
, Nicolle Breusing

Jan Frank, Andrew C Bulmer, Karl-Heinz Wagner (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

Original language	English
Article number	110234
Journal	Iscience
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.isci.2024.110234
Publication status	Published - 19 Jul 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

303009 Nutritional sciences

Keywords

human metabolism
pathology
public health

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10.1016/j.isci.2024.110234Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:2080700Licence: CC BY 4.0

Cite this

Schoissengeier, V., Maqboul, L., Weber, D., Grune, T., Bürkle, A., Moreno-Villaneuva, M., Franceschi, C., Capri, M., Bernhard, J., Toussaint, O., Debacq-Chainiaux, F., Weinberger, B., Gonos, E. S., Sikora, E., Dollé, M., Jansen, E., Slagboom, P. E., Hervonnen, A., Hurme, M., ... Wagner, K.-H. (2024). Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort. Iscience, 27(7), Article 110234. https://doi.org/10.1016/j.isci.2024.110234

@article{4237650188e843239f875e93f4a1c1ab,

title = "Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort",

abstract = "Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.",

keywords = "human metabolism, pathology, public health",

author = "Vanessa Schoissengeier and Lina Maqboul and Daniela Weber and Tilman Grune and Alexander B{\"u}rkle and Maria Moreno-Villaneuva and Claudio Franceschi and Miriam Capri and J{\"u}rgen Bernhard and Olivier Toussaint and Florence Debacq-Chainiaux and Birgit Weinberger and Gonos, \{Efstathios S\} and Ewa Sikora and Martijn Doll{\'e} and Eug{\`e}ne Jansen and Slagboom, \{P Eline\} and Antti Hervonnen and Mikko Hurme and Nicolle Breusing and Jan Frank and Bulmer, \{Andrew C\} and Karl-Heinz Wagner",

note = "{\textcopyright} 2024 The Authors. Published by Elsevier Inc.",

year = "2024",

month = jul,

day = "19",

doi = "10.1016/j.isci.2024.110234",

language = "English",

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Schoissengeier, V , Maqboul, L, Weber, D, Grune, T, Bürkle, A, Moreno-Villaneuva, M, Franceschi, C, Capri, M, Bernhard, J, Toussaint, O, Debacq-Chainiaux, F, Weinberger, B, Gonos, ES, Sikora, E, Dollé, M, Jansen, E, Slagboom, PE, Hervonnen, A, Hurme, M, Breusing, N, Frank, J, Bulmer, AC & Wagner, K-H 2024, 'Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort', Iscience, vol. 27, no. 7, 110234. https://doi.org/10.1016/j.isci.2024.110234

TY - JOUR

T1 - Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

AU - Schoissengeier, Vanessa

AU - Maqboul, Lina

AU - Weber, Daniela

AU - Grune, Tilman

AU - Bürkle, Alexander

AU - Moreno-Villaneuva, Maria

AU - Franceschi, Claudio

AU - Capri, Miriam

AU - Bernhard, Jürgen

AU - Toussaint, Olivier

AU - Debacq-Chainiaux, Florence

AU - Weinberger, Birgit

AU - Gonos, Efstathios S

AU - Sikora, Ewa

AU - Dollé, Martijn

AU - Jansen, Eugène

AU - Slagboom, P Eline

AU - Hervonnen, Antti

AU - Hurme, Mikko

AU - Breusing, Nicolle

AU - Frank, Jan

AU - Bulmer, Andrew C

AU - Wagner, Karl-Heinz

PY - 2024/7/19

Y1 - 2024/7/19

N2 - Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

AB - Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

KW - human metabolism

KW - pathology

KW - public health

UR - https://www.scopus.com/pages/publications/85196540049

U2 - 10.1016/j.isci.2024.110234

DO - 10.1016/j.isci.2024.110234

M3 - Article

C2 - 39021797

SN - 2589-0042

VL - 27

JO - Iscience

JF - Iscience

IS - 7

M1 - 110234

ER -

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Abstract

UN SDGs

Austrian Fields of Science 2012

Keywords

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