Atomistic mechanism of the constitutive activation of PDGFRA via its transmembrane domain

Anton A. Polyansky (Corresponding author), Eduard V. Bocharov, Amelie I. Velghe, Andrey S. Kuznetsov, Olga V. Bocharova, Anatoly S. Urban, Alexander S. Arseniev, Bojan Zagrovic, Jean-Baptiste Demoulin (Corresponding author), Roman G. Efremov

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)82-95
Number of pages14
JournalBiochimica et Biophysica Acta - General Subjects
Volume1863
Issue number1
DOIs
Publication statusPublished - Jan 2019

Austrian Fields of Science 2012

  • 106023 Molecular biology

Keywords

  • Receptor tyrosine kinases
  • Oncogenic mutations
  • Dimerization of transmembrane domains
  • Signal transduction
  • Molecular dynamics
  • NMR
  • HELIX-HELIX INTERACTIONS
  • MOLECULAR-DYNAMICS
  • CELL-TRANSFORMATION
  • EGFR TRANSMEMBRANE
  • SPATIAL STRUCTURE
  • RECEPTOR
  • DIMERIZATION
  • MEMBRANE
  • ASSOCIATION
  • DIMERS

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