Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells

Philipp Saiko; Maria Ozsvar-Kozma; Sibylle Madlener; Astrid Bernhaus; Andreas Lackner; Michael Grusch; Zsuzsanna Horvath; Georg Krupitza; Walter Jaeger; Kirsten Ammer; Monika Fritzer-Szekeres; Thomas Szekeres

doi:10.1016/j.canlet.2006.10.018

Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells

Philipp Saiko, Maria Ozsvar-Kozma, Sibylle Madlener, Astrid Bernhaus, Andreas Lackner, Michael Grusch, Zsuzsanna Horvath, Georg Krupitza, Walter Jaeger, Kirsten Ammer, Monika Fritzer-Szekeres, Thomas Szekeres

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC₅₀ values of 400, 190, and 160 μg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of the cell cycle and was also found to significantly reduce the in situ activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.

Original language	English
Pages (from-to)	323-328
Number of pages	6
Journal	Cancer Letters
Volume	250
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2006.10.018
Publication status	Published - 8 Jun 2007

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

Apoptosis
Avemar
Cell cycle
HL-60 cells
Ribonucleotide reductase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Saiko, P., Ozsvar-Kozma, M., Madlener, S., Bernhaus, A., Lackner, A., Grusch, M., Horvath, Z., Krupitza, G., Jaeger, W., Ammer, K., Fritzer-Szekeres, M., & Szekeres, T. (2007). Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells. Cancer Letters, 250(2), 323-328. https://doi.org/10.1016/j.canlet.2006.10.018

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title = "Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells",

abstract = "Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 μg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of the cell cycle and was also found to significantly reduce the in situ activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.",

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author = "Philipp Saiko and Maria Ozsvar-Kozma and Sibylle Madlener and Astrid Bernhaus and Andreas Lackner and Michael Grusch and Zsuzsanna Horvath and Georg Krupitza and Walter Jaeger and Kirsten Ammer and Monika Fritzer-Szekeres and Thomas Szekeres",

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Saiko, P, Ozsvar-Kozma, M, Madlener, S, Bernhaus, A, Lackner, A, Grusch, M, Horvath, Z, Krupitza, G, Jaeger, W, Ammer, K, Fritzer-Szekeres, M & Szekeres, T 2007, 'Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells', Cancer Letters, vol. 250, no. 2, pp. 323-328. https://doi.org/10.1016/j.canlet.2006.10.018

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T1 - Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells

AU - Saiko, Philipp

AU - Ozsvar-Kozma, Maria

AU - Madlener, Sibylle

AU - Bernhaus, Astrid

AU - Lackner, Andreas

AU - Grusch, Michael

AU - Horvath, Zsuzsanna

AU - Krupitza, Georg

AU - Jaeger, Walter

AU - Ammer, Kirsten

AU - Fritzer-Szekeres, Monika

AU - Szekeres, Thomas

PY - 2007/6/8

Y1 - 2007/6/8

N2 - Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 μg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of the cell cycle and was also found to significantly reduce the in situ activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.

AB - Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 μg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated the progression from G2-M to G0-G1 phase of the cell cycle and was also found to significantly reduce the in situ activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis. We conclude that Avemar exerts a number of beneficial effects which could support conventional chemotherapy of human malignancies.

KW - Apoptosis

KW - Avemar

KW - Cell cycle

KW - HL-60 cells

KW - Ribonucleotide reductase

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ER -

Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells

Abstract

Austrian Fields of Science 2012

Keywords

UN SDGs

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