Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

Ekaterina Schreiber-Brynzak; Verena Pichler; Petra Heffeter; Buck Hanson; Sarah Theiner; Irene Lichtscheidl-Schultz; Christoph Kornauth; Luca Bamonti; Vineet Dhery; Diana Groza; David Berry; Walter Berger; Mathea Sophia Galanski; Michael A. Jakupec; Bernhard K. Keppler

doi:10.1039/c5mt00312a

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

Ekaterina Schreiber-Brynzak
, Verena Pichler
, Petra Heffeter
, Buck Hanson
, Sarah Theiner
, Irene Lichtscheidl-Schultz
, Christoph Kornauth
, Luca Bamonti
, Vineet Dhery
, Diana Groza
, David Berry
, Walter Berger
, Mathea Sophia Galanski
, Michael A. Jakupec (Corresponding author)
, Bernhard K. Keppler

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	422-433
Number of pages	12
Journal	Metallomics: integrated biometal science
Volume	8
Issue number	4
DOIs	https://doi.org/10.1039/c5mt00312a
Publication status	Published - Apr 2016

Funding

These studies were performed in cooperation with different institutes and groups, as well as single persons; therefore, we would like to thank all partners for cooperation and support of this study. First of all, we want to acknowledge financial support provided by the Vienna Science and Technology Fund (Project LS12-001) and FWF (projects P26127-B20 and P26603), which made our work possible. We are also grateful to Sushilla van Schoonhoven and Gerhard Zeitler for technical support. This project was carried out in the surrounding of COST Action CM1105.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301904 Cancer research
106002 Biochemistry
106023 Molecular biology

Keywords

SOLID TUMORS
CELL-LINES
SATRAPLATIN
SPHEROIDS
CANCER
CISPLATIN
CHEMOTHERAPY
DRUGS
PHARMACOKINETICS
RESISTANCE

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10.1039/c5mt00312aLicence: CC BY 3.0

http://phaidra.univie.ac.at/o:520620Licence: CC BY 3.0

Cite this

Schreiber-Brynzak, E., Pichler, V., Heffeter, P., Hanson, B., Theiner, S., Lichtscheidl-Schultz, I., Kornauth, C., Bamonti, L., Dhery, V., Groza, D., Berry, D., Berger, W., Galanski, M. S., Jakupec, M. A., & Keppler, B. K. (2016). Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation. Metallomics: integrated biometal science, 8(4), 422-433. https://doi.org/10.1039/c5mt00312a

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title = "Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation",

keywords = "SOLID TUMORS, CELL-LINES, SATRAPLATIN, SPHEROIDS, CANCER, CISPLATIN, CHEMOTHERAPY, DRUGS, PHARMACOKINETICS, RESISTANCE",

author = "Ekaterina Schreiber-Brynzak and Verena Pichler and Petra Heffeter and Buck Hanson and Sarah Theiner and Irene Lichtscheidl-Schultz and Christoph Kornauth and Luca Bamonti and Vineet Dhery and Diana Groza and David Berry and Walter Berger and Galanski, \{Mathea Sophia\} and Jakupec, \{Michael A.\} and Keppler, \{Bernhard K.\}",

note = " Accession Number: WOS:000374788300005 ",

year = "2016",

month = apr,

doi = "10.1039/c5mt00312a",

language = "English",

volume = "8",

pages = "422--433",

journal = "Metallomics: integrated biometal science",

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Schreiber-Brynzak, E, Pichler, V, Heffeter, P, Hanson, B, Theiner, S, Lichtscheidl-Schultz, I, Kornauth, C, Bamonti, L, Dhery, V, Groza, D, Berry, D, Berger, W, Galanski, MS , Jakupec, MA & Keppler, BK 2016, 'Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation', Metallomics: integrated biometal science, vol. 8, no. 4, pp. 422-433. https://doi.org/10.1039/c5mt00312a

TY - JOUR

T1 - Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

AU - Schreiber-Brynzak, Ekaterina

AU - Pichler, Verena

AU - Heffeter, Petra

AU - Hanson, Buck

AU - Theiner, Sarah

AU - Lichtscheidl-Schultz, Irene

AU - Kornauth, Christoph

AU - Bamonti, Luca

AU - Dhery, Vineet

AU - Groza, Diana

AU - Berry, David

AU - Berger, Walter

AU - Galanski, Mathea Sophia

AU - Jakupec, Michael A.

AU - Keppler, Bernhard K.

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PY - 2016/4

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KW - CELL-LINES

KW - SATRAPLATIN

KW - SPHEROIDS

KW - CANCER

KW - CISPLATIN

KW - CHEMOTHERAPY

KW - DRUGS

KW - PHARMACOKINETICS

KW - RESISTANCE

UR - https://www.scopus.com/pages/publications/84969530902

U2 - 10.1039/c5mt00312a

DO - 10.1039/c5mt00312a

M3 - Article

C2 - 26860208

SN - 1756-5901

VL - 8

SP - 422

EP - 433

JO - Metallomics: integrated biometal science

JF - Metallomics: integrated biometal science

IS - 4

ER -

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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