Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

Maria S. Legina, Juan J. Nogueira, Wolfgang Kandioller, Michael A. Jakupec (Corresponding author), Leticia Gonzalez, Bernhard K. Keppler

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)451-465
Number of pages15
JournalJournal of Biological Inorganic Chemistry
Volume25
Issue number3
DOIs
Publication statusPublished - May 2020

Austrian Fields of Science 2012

  • 104003 Inorganic chemistry
  • 104004 Chemical biology
  • 301904 Cancer research

Keywords

  • Topoisomerase II alpha
  • Metal complex
  • Anticancer drug
  • Molecular dynamics
  • Monte Carlo simulation
  • RNA interference
  • PROTEIN SIDE-CHAIN
  • H2AX PHOSPHORYLATION
  • CELL-CYCLE
  • DNA
  • CANCER
  • CHEMOSENSITIVITY
  • PARAMETERS
  • RESISTANCE
  • EXPRESSION
  • DIVISION
  • Topoisomerase IIα

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