Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

Maria S. Legina; Juan J. Nogueira; Wolfgang Kandioller; Michael A. Jakupec; Leticia Gonzalez; Bernhard K. Keppler

doi:10.1007/s00775-020-01775-2

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

Maria S. Legina
, Juan J. Nogueira
, Wolfgang Kandioller
, Michael A. Jakupec (Corresponding author)
, Leticia Gonzalez
, Bernhard K. Keppler

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	451-465
Number of pages	15
Journal	Journal of Biological Inorganic Chemistry
Volume	25
Issue number	3
DOIs	https://doi.org/10.1007/s00775-020-01775-2
Publication status	Published - May 2020

Funding

Open access funding provided by University of Vienna. The authors would like to thank the Johanna Mahlke nee Obermann Foundation for financial support within the project "Exploring Novel Protein Targets of Anticancer Metal Compounds". JJN acknowledges funding from Comunidad de Madrid through the Attraction of Talent Program 2018, Grant Ref. 2018-T1/BMD-10261. The Vienna Scientific Cluster is acknowledged for generous computational support.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

104003 Inorganic chemistry
104004 Chemical biology
301904 Cancer research

Keywords

Topoisomerase II alpha
Metal complex
Anticancer drug
Molecular dynamics
Monte Carlo simulation
RNA interference
PROTEIN SIDE-CHAIN
H2AX PHOSPHORYLATION
CELL-CYCLE
DNA
CANCER
CHEMOSENSITIVITY
PARAMETERS
RESISTANCE
EXPRESSION
DIVISION
Topoisomerase IIα

Access to Document

10.1007/s00775-020-01775-2Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1218381Licence: CC BY 4.0

Cite this

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title = "Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors",

keywords = "Topoisomerase II alpha, Metal complex, Anticancer drug, Molecular dynamics, Monte Carlo simulation, RNA interference, PROTEIN SIDE-CHAIN, H2AX PHOSPHORYLATION, CELL-CYCLE, DNA, CANCER, CHEMOSENSITIVITY, PARAMETERS, RESISTANCE, EXPRESSION, DIVISION, Topoisomerase IIα",

author = "Legina, \{Maria S.\} and Nogueira, \{Juan J.\} and Wolfgang Kandioller and Jakupec, \{Michael A.\} and Leticia Gonzalez and Keppler, \{Bernhard K.\}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = may,

doi = "10.1007/s00775-020-01775-2",

language = "English",

volume = "25",

pages = "451--465",

journal = "Journal of Biological Inorganic Chemistry",

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TY - JOUR

T1 - Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

AU - Legina, Maria S.

AU - Nogueira, Juan J.

AU - Kandioller, Wolfgang

AU - Jakupec, Michael A.

AU - Gonzalez, Leticia

AU - Keppler, Bernhard K.

PY - 2020/5

Y1 - 2020/5

KW - Topoisomerase II alpha

KW - Metal complex

KW - Anticancer drug

KW - Molecular dynamics

KW - Monte Carlo simulation

KW - RNA interference

KW - PROTEIN SIDE-CHAIN

KW - H2AX PHOSPHORYLATION

KW - CELL-CYCLE

KW - DNA

KW - CANCER

KW - CHEMOSENSITIVITY

KW - PARAMETERS

KW - RESISTANCE

KW - EXPRESSION

KW - DIVISION

KW - Topoisomerase IIα

UR - https://www.scopus.com/pages/publications/85082863823

U2 - 10.1007/s00775-020-01775-2

DO - 10.1007/s00775-020-01775-2

M3 - Article

SN - 0949-8257

VL - 25

SP - 451

EP - 465

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

IS - 3

ER -

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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