Branched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Zhengnan Cai, Wan Li, Martin Brenner, Sheyda Bahiraii, Elke H Heiss, Wolfram Weckwerth

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Article number966158
Number of pages14
JournalFrontiers in Immunology
Issue number13
DOIs
Publication statusPublished - 13 Oct 2022

Austrian Fields of Science 2012

  • 301209 Pharmacy

Keywords

  • Animals
  • Humans
  • Mice
  • Proteomics
  • Macrophage Activation
  • Biological Transport
  • Phagocytosis
  • Macrophages
  • Neoplasms
  • apoptosis
  • macrophage polarization
  • BCKAs Fc-gamma receptor (FCgR)-mediated phagocytosis
  • tumor necrosis factor alpha (TNFα)-nuclear factor kappa B (NFκB) -mediated inflammatory pathway
  • tumor-associated macrophages
  • panomics
  • AMINO-ACID-METABOLISM
  • LACTATE
  • GROWTH
  • CYTOSCAPE
  • IDENTIFICATION
  • tumor necrosis factor alpha (TNFa)-nuclear factor kappa B (NF?B)-mediated inflammatory pathway
  • POOR-PROGNOSIS
  • TUMOR-ASSOCIATED MACROPHAGES
  • CORRELATE
  • PROMOTES

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