Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

Julia H. Bormio Nunes; Sonja Hager; Marlene Mathuber; Vivien Pósa; Alexander Roller; Eva A. Enyedy; Alessia Stefanelli; Walter Berger; Bernhard K. Keppler; Petra Heffeter; Christian R. Kowol

doi:10.1021/acs.jmedchem.0c01277

Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

Julia H. Bormio Nunes
, Sonja Hager
, Marlene Mathuber
, Vivien Pósa
, Alexander Roller
, Eva A. Enyedy
, Alessia Stefanelli
, Walter Berger
, Bernhard K. Keppler
, Petra Heffeter (Corresponding author)
, Christian R. Kowol (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	13719-13732
Number of pages	14
Journal	Journal of Medicinal Chemistry
Volume	63
Issue number	22
DOIs	https://doi.org/10.1021/acs.jmedchem.0c01277
Publication status	Published - 25 Nov 2020

Funding

This work was supported by the Austrian Science Fund (FWF) grant P31923 (to C.R.K. and P.H.). J.H.B.N. would like to thank Österreichischer Austauschdienst (OeAD) for her Ernst Mach Grant—worldwide. Furthermore, we thank the bilateral OeAD project HU 02/2020. A.S. was employed by the Doc-Funds project “International PhD program translational oncology” (IPPTO) by the FWF, and S.H. was funded by the DOC Fellowship of the Austrian Academy of Sciences. This work was supported by National Research, Development and Innovation Office-NKFIA through project FK 124240 and Ministry of Human Capacities, Hungary grant, TKP-2020. We thank Jennifer Hsu for establishing the COTI-resistant SW480/Coti cells.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301305 Medical chemistry
301904 Cancer research

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Bormio Nunes, J. H., Hager, S., Mathuber, M., Pósa, V., Roller, A., Enyedy, E. A., Stefanelli, A., Berger, W., Keppler, B. K., Heffeter, P., & Kowol, C. R. (2020). Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux. Journal of Medicinal Chemistry, 63(22), 13719-13732. https://doi.org/10.1021/acs.jmedchem.0c01277

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title = "Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux",

author = "\{Bormio Nunes\}, \{Julia H.\} and Sonja Hager and Marlene Mathuber and Vivien P{\'o}sa and Alexander Roller and Enyedy, \{Eva A.\} and Alessia Stefanelli and Walter Berger and Keppler, \{Bernhard K.\} and Petra Heffeter and Kowol, \{Christian R.\}",

note = "Accession Number: WOS:000595545900029 PubMed ID: 33190481 ",

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doi = "10.1021/acs.jmedchem.0c01277",

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Bormio Nunes, JH, Hager, S, Mathuber, M, Pósa, V, Roller, A, Enyedy, EA, Stefanelli, A, Berger, W, Keppler, BK, Heffeter, P & Kowol, CR 2020, 'Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux', Journal of Medicinal Chemistry, vol. 63, no. 22, pp. 13719-13732. https://doi.org/10.1021/acs.jmedchem.0c01277

Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux. / Bormio Nunes, Julia H.; Hager, Sonja; Mathuber, Marlene et al.
In: Journal of Medicinal Chemistry, Vol. 63, No. 22, 25.11.2020, p. 13719-13732.

Publications: Contribution to journal › Article › Peer Reviewed

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AU - Bormio Nunes, Julia H.

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AU - Mathuber, Marlene

AU - Pósa, Vivien

AU - Roller, Alexander

AU - Enyedy, Eva A.

AU - Stefanelli, Alessia

AU - Berger, Walter

AU - Keppler, Bernhard K.

AU - Heffeter, Petra

AU - Kowol, Christian R.

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SN - 0022-2623

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Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

Funding

UN SDGs

Austrian Fields of Science 2012

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