TY - JOUR
T1 - Capillary electrophoresis of platinum-group elements: Analytical, speciation and biochemical studies
AU - Keppler, Bernhard
AU - Timerbaev, Andrei
N1 - Küng, Angelika
Zeitschrift: Journal of Chromatography A
DOI: 10.1016/S0021-9673(01)01489-3
Coden: JCRAE
Affiliations: Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin Street 19, 117975 Moscow, Russian Federation; Institute of Inorganic Chemistry, University of Vienna, Wa¿hringer Strasse 42, A-1090 Vienna, Austria
Adressen: Timerbaev, A.R.; Vernadsky Inst. Geochem./Anal. Chem.; Russian Academy of Sciences; Kosygin Street 19 117975 Moscow, Russian Federation; email: [email protected]
Source-File: ChemieErgScopus.csv
Import aus Scopus: 2-s2.0-0036470083
Importdatum: 09.01.2007 14:12:13
12.02.2008: Datenanforderung 2112 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2002
Y1 - 2002
N2 - A great deal of research has been carried out in recent years on developing high-efficiency capillary electrophoresis (CE) techniques that are able to separate rapidly and selectively ionic platinum metal species in a wide variety of their complexed forms. Using a range of illustrative examples, this review examines the potential and utilization of various CE separation approaches and detection modes in this expanding area. Also covered are CE procedures suitable for solving practical analytical problems and for platinum metal speciation purposes. Presenting a comprehensive treatise on the evolving practices of CE concerning platinum anticancer drugs - in particular, the examination of the stability of intact drugs, the separation and identification of products of their metabolism and interactions with biomolecules (including kinetic studies of the binding behavior) - this paper witnesses a welcome shift of the main research activities to those performed under physiological conditions. Π2002 Elsevier Science B.V. All rights reserved.
AB - A great deal of research has been carried out in recent years on developing high-efficiency capillary electrophoresis (CE) techniques that are able to separate rapidly and selectively ionic platinum metal species in a wide variety of their complexed forms. Using a range of illustrative examples, this review examines the potential and utilization of various CE separation approaches and detection modes in this expanding area. Also covered are CE procedures suitable for solving practical analytical problems and for platinum metal speciation purposes. Presenting a comprehensive treatise on the evolving practices of CE concerning platinum anticancer drugs - in particular, the examination of the stability of intact drugs, the separation and identification of products of their metabolism and interactions with biomolecules (including kinetic studies of the binding behavior) - this paper witnesses a welcome shift of the main research activities to those performed under physiological conditions. Π2002 Elsevier Science B.V. All rights reserved.
U2 - 10.1016/S0021-9673(01)01489-3
DO - 10.1016/S0021-9673(01)01489-3
M3 - Review
SN - 0021-9673
VL - 945
SP - 25
EP - 44
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1-2
ER -