CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

Magdalena Billerhart, Monika Schonhofer, Hemma Schueffl, Wolfram Polzer, Simon Decker, Alexander Taschauer, Julia Maier, Martina Anton, Sebastian Eckmann, Manuel Blaschek, Julia Pichler, Petra Heffeter, Haider Sami (Corresponding author), Manfred Ogris (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)192-204
Number of pages13
JournalMolecular therapy-Oncolytics
Volume23
DOIs
Publication statusPublished - 17 Dec 2021

Austrian Fields of Science 2012

  • 304004 Gene therapy
  • 301904 Cancer research
  • 301213 Drug targeting
  • 301212 Clinical pharmacy

Keywords

  • TRANSGENE EXPRESSION
  • ANTITUMOR-ACTIVITY
  • CD47 BLOCKADE
  • GENE-THERAPY
  • IN-VITRO
  • ALPHA
  • DELIVERY
  • VARIANTS
  • AFFINITY
  • VECTOR
  • NK cells
  • transfection
  • gene therapy
  • macrophage
  • immunogene therapy
  • Fc receptor
  • CD47
  • polyplex
  • signal regulatory protein alpha

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