CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

Magdalena Billerhart; Monika Schonhofer; Hemma Schueffl; Wolfram Polzer; Simon Decker; Alexander Taschauer; Julia Maier; Martina Anton; Sebastian Eckmann; Manuel Blaschek; Julia Pichler; Petra Heffeter; Haider Sami; Manfred Ogris

doi:10.1016/j.omto.2021.09.005

CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

Magdalena Billerhart
, Monika Schonhofer
, Hemma Schueffl
, Wolfram Polzer
, Simon Decker
, Alexander Taschauer
, Julia Maier
, Martina Anton
, Sebastian Eckmann
, Manuel Blaschek
, Julia Pichler
, Petra Heffeter
, Haider Sami (Corresponding author)
, Manfred Ogris (Corresponding author)

Department of Pharmaceutical Sciences

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	192-204
Number of pages	13
Journal	Molecular therapy-Oncolytics
Volume	23
DOIs	https://doi.org/10.1016/j.omto.2021.09.005
Publication status	Published - 17 Dec 2021

Funding

This work was in part co-funded by a grant from the Austrian Research Promotion Agency (FFG) .

Austrian Fields of Science 2012

304004 Gene therapy
301904 Cancer research
301213 Drug targeting
301212 Clinical pharmacy

Keywords

TRANSGENE EXPRESSION
ANTITUMOR-ACTIVITY
CD47 BLOCKADE
GENE-THERAPY
IN-VITRO
ALPHA
DELIVERY
VARIANTS
AFFINITY
VECTOR
NK cells
transfection
gene therapy
macrophage
immunogene therapy
Fc receptor
CD47
polyplex
signal regulatory protein alpha

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.omto.2021.09.005Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1588270Licence: CC BY 4.0

Cite this

Billerhart, M., Schonhofer, M., Schueffl, H., Polzer, W., Decker, S., Taschauer, A., Maier, J., Anton, M., Eckmann, S., Blaschek, M., Pichler, J., Heffeter, P., Sami, H., & Ogris, M. (2021). CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation. Molecular therapy-Oncolytics, 23, 192-204. https://doi.org/10.1016/j.omto.2021.09.005

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title = "CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation",

keywords = "TRANSGENE EXPRESSION, ANTITUMOR-ACTIVITY, CD47 BLOCKADE, GENE-THERAPY, IN-VITRO, ALPHA, DELIVERY, VARIANTS, AFFINITY, VECTOR, NK cells, transfection, gene therapy, macrophage, immunogene therapy, Fc receptor, CD47, polyplex, signal regulatory protein alpha",

author = "Magdalena Billerhart and Monika Schonhofer and Hemma Schueffl and Wolfram Polzer and Simon Decker and Alexander Taschauer and Julia Maier and Martina Anton and Sebastian Eckmann and Manuel Blaschek and Julia Pichler and Petra Heffeter and Haider Sami and Manfred Ogris",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = dec,

day = "17",

doi = "10.1016/j.omto.2021.09.005",

language = "English",

volume = "23",

pages = "192--204",

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Billerhart, M, Schonhofer, M, Schueffl, H, Polzer, W, Decker, S, Taschauer, A, Maier, J, Anton, M, Eckmann, S, Blaschek, M, Pichler, J, Heffeter, P, Sami, H & Ogris, M 2021, 'CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation', Molecular therapy-Oncolytics, vol. 23, pp. 192-204. https://doi.org/10.1016/j.omto.2021.09.005

TY - JOUR

T1 - CD47-targeted cancer immunogene therapy

T2 - Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

AU - Billerhart, Magdalena

AU - Schonhofer, Monika

AU - Schueffl, Hemma

AU - Polzer, Wolfram

AU - Decker, Simon

AU - Taschauer, Alexander

AU - Maier, Julia

AU - Anton, Martina

AU - Eckmann, Sebastian

AU - Blaschek, Manuel

AU - Pichler, Julia

AU - Heffeter, Petra

AU - Sami, Haider

AU - Ogris, Manfred

PY - 2021/12/17

Y1 - 2021/12/17

KW - TRANSGENE EXPRESSION

KW - ANTITUMOR-ACTIVITY

KW - CD47 BLOCKADE

KW - GENE-THERAPY

KW - IN-VITRO

KW - ALPHA

KW - DELIVERY

KW - VARIANTS

KW - AFFINITY

KW - VECTOR

KW - NK cells

KW - transfection

KW - gene therapy

KW - macrophage

KW - immunogene therapy

KW - Fc receptor

KW - CD47

KW - polyplex

KW - signal regulatory protein alpha

UR - https://www.scopus.com/pages/publications/85122631336

U2 - 10.1016/j.omto.2021.09.005

DO - 10.1016/j.omto.2021.09.005

M3 - Article

C2 - 34729396

SN - 2372-7705

VL - 23

SP - 192

EP - 204

JO - Molecular therapy-Oncolytics

JF - Molecular therapy-Oncolytics

ER -

CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

Funding

Austrian Fields of Science 2012

Keywords

UN SDGs

Access to Document

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