Abstract
Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.
Original language | English |
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Pages (from-to) | 2694−2711 |
Number of pages | 18 |
Journal | Current Topics in Medicinal Chemistry |
Volume | 14 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2014 |
Austrian Fields of Science 2012
- 301207 Pharmaceutical chemistry
Keywords
- Anticancer drugs
- Antidiabetic drugs
- Biocatalysis
- Carbohydrates
- Glycomimetic