Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

Andres R. Alcántara, Vittorio Pace, Pilar Hoyos, Manuel Sandoval, Wolfgang Holzer, María J. Hernáiz (Corresponding author)

    Publications: Contribution to journalReviewPeer Reviewed

    Abstract

    Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.
    Original languageEnglish
    Pages (from-to)2694−2711
    Number of pages18
    JournalCurrent Topics in Medicinal Chemistry
    Volume14
    Issue number23
    DOIs
    Publication statusPublished - 2014

    Austrian Fields of Science 2012

    • 301207 Pharmaceutical chemistry

    Keywords

    • Anticancer drugs
    • Antidiabetic drugs
    • Biocatalysis
    • Carbohydrates
    • Glycomimetic

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