Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides

Vittorio Pace; Wolfgang Holzer; Guido Verniest; Andres R. Alcantara; Norbert De Kimpe

doi:10.1002/adsc.201201043

Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides

Vittorio Pace (Corresponding author)
, Wolfgang Holzer
, Guido Verniest
, Andres R. Alcantara
, Norbert De Kimpe (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	919-926
Number of pages	8
Journal	Advanced Synthesis & Catalysis
Volume	355
Issue number	5
DOIs	https://doi.org/10.1002/adsc.201201043
Publication status	Published - Mar 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

104013 Natural product chemistry

Keywords

carbenoids
halides
lithiation
nucleophilic substitution
Weinreb amides
HIV PROTEASE INHIBITORS
CARBONYL-COMPOUNDS
DIASTEREOSELECTIVE SYNTHESIS
BROMOMETHYL KETONES
PRACTICAL SYNTHESIS
ESTER HOMOLOGATION
ADDITION-REACTIONS
ORGANIC-SYNTHESIS
ACIDS
DIAZOMETHANE

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10.1002/adsc.201201043

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@article{f13b623eb68d46418d9436ca271f55f3,

title = "Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides",

keywords = "carbenoids, halides, lithiation, nucleophilic substitution, Weinreb amides, HIV PROTEASE INHIBITORS, CARBONYL-COMPOUNDS, DIASTEREOSELECTIVE SYNTHESIS, BROMOMETHYL KETONES, PRACTICAL SYNTHESIS, ESTER HOMOLOGATION, ADDITION-REACTIONS, ORGANIC-SYNTHESIS, ACIDS, DIAZOMETHANE",

author = "Vittorio Pace and Wolfgang Holzer and Guido Verniest and Alcantara, \{Andres R.\} and \{De Kimpe\}, Norbert",

year = "2013",

month = mar,

doi = "10.1002/adsc.201201043",

language = "English",

volume = "355",

pages = "919--926",

journal = "Advanced Synthesis \& Catalysis",

issn = "1615-4150",

publisher = "WILEY-V C H VERLAG GMBH",

number = "5",

}

TY - JOUR

T1 - Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides

AU - Pace, Vittorio

AU - Holzer, Wolfgang

AU - Verniest, Guido

AU - Alcantara, Andres R.

AU - De Kimpe, Norbert

PY - 2013/3

Y1 - 2013/3

KW - carbenoids

KW - halides

KW - lithiation

KW - nucleophilic substitution

KW - Weinreb amides

KW - HIV PROTEASE INHIBITORS

KW - CARBONYL-COMPOUNDS

KW - DIASTEREOSELECTIVE SYNTHESIS

KW - BROMOMETHYL KETONES

KW - PRACTICAL SYNTHESIS

KW - ESTER HOMOLOGATION

KW - ADDITION-REACTIONS

KW - ORGANIC-SYNTHESIS

KW - ACIDS

KW - DIAZOMETHANE

U2 - 10.1002/adsc.201201043

DO - 10.1002/adsc.201201043

M3 - Article

SN - 1615-4150

VL - 355

SP - 919

EP - 926

JO - Advanced Synthesis & Catalysis

JF - Advanced Synthesis & Catalysis

IS - 5

ER -

Chemoselective Synthesis of N-Substituted alpha-Amino-alpha '-chloro Ketones via Chloromethylation of Glycine-Derived Weinreb Amides

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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