Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Mohamed Elgendy; Marco Cirò; Amir Hosseini; Jakob Weiszmann; Luca Mazzarella; Elisa Ferrari; Riccardo Cazzoli; Giuseppe Curigliano; Andrea DeCensi; Bernardo Bonanni; Alfredo Budillon; Pier Giuseppe Pelicci; Veerle Janssens; Manfred Ogris; Manuela Baccarini; Luisa Lanfrancone; Wolfram Weckwerth; Marco Foiani; Saverio Minucci

doi:10.1016/j.ccell.2019.03.007

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Mohamed Elgendy, Marco Cirò, Amir Hosseini, Jakob Weiszmann, Luca Mazzarella, Elisa Ferrari, Riccardo Cazzoli, Giuseppe Curigliano, Andrea DeCensi, Bernardo Bonanni, Alfredo Budillon, Pier Giuseppe Pelicci, Veerle Janssens, Manfred Ogris, Manuela Baccarini, Luisa Lanfrancone, Wolfram Weckwerth, Marco Foiani, Saverio Minucci

Department of Microbiology, Immunobiology and Genetics

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	798-815.e5
Number of pages	23
Journal	Cancer Cell
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2019.03.007
Publication status	Published - 2019

Austrian Fields of Science 2012

301206 Pharmacology

Keywords

metformin
glucose
hypoglycemia
fasting
caloric restriction
MCL-1
GSK3ß
PP2A
metabolic plasticity
tumor metabolism
APOPTOSIS
SUPPRESSOR
ACTIVATION
KINASE
BREAST-CANCER PROLIFERATION
RESTRICTION
RESISTANCE
DEGRADATION
TUMORIGENESIS
MCL1

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10.1016/j.ccell.2019.03.007

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Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M., & Minucci, S. (2019). Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis. Cancer Cell, 35(5), 798-815.e5. https://doi.org/10.1016/j.ccell.2019.03.007

@article{fdcd36865fe24e828618a2643bb78a76,

title = "Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis",

keywords = "metformin, glucose, hypoglycemia, fasting, caloric restriction, MCL-1, GSK3{\ss}, PP2A, metabolic plasticity, tumor metabolism, APOPTOSIS, SUPPRESSOR, ACTIVATION, KINASE, BREAST-CANCER PROLIFERATION, RESTRICTION, RESISTANCE, DEGRADATION, TUMORIGENESIS, MCL1",

author = "Mohamed Elgendy and Marco Cir{\`o} and Amir Hosseini and Jakob Weiszmann and Luca Mazzarella and Elisa Ferrari and Riccardo Cazzoli and Giuseppe Curigliano and Andrea DeCensi and Bernardo Bonanni and Alfredo Budillon and Pelicci, {Pier Giuseppe} and Veerle Janssens and Manfred Ogris and Manuela Baccarini and Luisa Lanfrancone and Wolfram Weckwerth and Marco Foiani and Saverio Minucci",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

doi = "10.1016/j.ccell.2019.03.007",

language = "English",

volume = "35",

pages = "798--815.e5",

journal = "Cancer Cell",

issn = "1535-6108",

number = "5",

}

Elgendy, M, Cirò, M, Hosseini, A, Weiszmann, J, Mazzarella, L, Ferrari, E, Cazzoli, R, Curigliano, G, DeCensi, A, Bonanni, B, Budillon, A, Pelicci, PG, Janssens, V, Ogris, M , Baccarini, M, Lanfrancone, L, Weckwerth, W, Foiani, M & Minucci, S 2019, 'Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis', Cancer Cell, vol. 35, no. 5, pp. 798-815.e5. https://doi.org/10.1016/j.ccell.2019.03.007

TY - JOUR

T1 - Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

AU - Elgendy, Mohamed

AU - Cirò, Marco

AU - Hosseini, Amir

AU - Weiszmann, Jakob

AU - Mazzarella, Luca

AU - Ferrari, Elisa

AU - Cazzoli, Riccardo

AU - Curigliano, Giuseppe

AU - DeCensi, Andrea

AU - Bonanni, Bernardo

AU - Budillon, Alfredo

AU - Pelicci, Pier Giuseppe

AU - Janssens, Veerle

AU - Ogris, Manfred

AU - Baccarini, Manuela

AU - Lanfrancone, Luisa

AU - Weckwerth, Wolfram

AU - Foiani, Marco

AU - Minucci, Saverio

PY - 2019

Y1 - 2019

KW - metformin

KW - glucose

KW - hypoglycemia

KW - fasting

KW - caloric restriction

KW - MCL-1

KW - GSK3ß

KW - PP2A

KW - metabolic plasticity

KW - tumor metabolism

KW - APOPTOSIS

KW - SUPPRESSOR

KW - ACTIVATION

KW - KINASE

KW - BREAST-CANCER PROLIFERATION

KW - RESTRICTION

KW - RESISTANCE

KW - DEGRADATION

KW - TUMORIGENESIS

KW - MCL1

UR - http://www.scopus.com/inward/record.url?scp=85065108746&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2019.03.007

DO - 10.1016/j.ccell.2019.03.007

M3 - Article

C2 - 31031016

SN - 1535-6108

VL - 35

SP - 798-815.e5

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Austrian Fields of Science 2012

Keywords

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