Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Mohamed Elgendy; Marco Cirò; Amir Hosseini; Jakob Weiszmann; Luca Mazzarella; Elisa Ferrari; Riccardo Cazzoli; Giuseppe Curigliano; Andrea DeCensi; Bernardo Bonanni; Alfredo Budillon; Pier Giuseppe Pelicci; Veerle Janssens; Manfred Ogris; Manuela Baccarini; Luisa Lanfrancone; Wolfram Weckwerth; Marco Foiani; Saverio Minucci

doi:10.1016/j.ccell.2019.03.007

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Mohamed Elgendy
, Marco Cirò
, Amir Hosseini
, Jakob Weiszmann
, Luca Mazzarella
, Elisa Ferrari
, Riccardo Cazzoli
, Giuseppe Curigliano
, Andrea DeCensi
, Bernardo Bonanni
, Alfredo Budillon
, Pier Giuseppe Pelicci
, Veerle Janssens
, Manfred Ogris
, Manuela Baccarini
, Luisa Lanfrancone
, Wolfram Weckwerth
, Marco Foiani
, Saverio Minucci

Max Perutz Labs - 746

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	798-815.e5
Number of pages	23
Journal	Cancer Cell
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2019.03.007
Publication status	Published - 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301206 Pharmacology

Keywords

metformin
glucose
hypoglycemia
fasting
caloric restriction
MCL-1
GSK3ß
PP2A
metabolic plasticity
tumor metabolism
APOPTOSIS
SUPPRESSOR
ACTIVATION
KINASE
BREAST-CANCER PROLIFERATION
RESTRICTION
RESISTANCE
DEGRADATION
TUMORIGENESIS
MCL1

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10.1016/j.ccell.2019.03.007

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Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M., & Minucci, S. (2019). Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis. Cancer Cell, 35(5), 798-815.e5. https://doi.org/10.1016/j.ccell.2019.03.007

@article{fdcd36865fe24e828618a2643bb78a76,

title = "Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis",

keywords = "metformin, glucose, hypoglycemia, fasting, caloric restriction, MCL-1, GSK3{\ss}, PP2A, metabolic plasticity, tumor metabolism, APOPTOSIS, SUPPRESSOR, ACTIVATION, KINASE, BREAST-CANCER PROLIFERATION, RESTRICTION, RESISTANCE, DEGRADATION, TUMORIGENESIS, MCL1",

author = "Mohamed Elgendy and Marco Cir{\`o} and Amir Hosseini and Jakob Weiszmann and Luca Mazzarella and Elisa Ferrari and Riccardo Cazzoli and Giuseppe Curigliano and Andrea DeCensi and Bernardo Bonanni and Alfredo Budillon and Pelicci, \{Pier Giuseppe\} and Veerle Janssens and Manfred Ogris and Manuela Baccarini and Luisa Lanfrancone and Wolfram Weckwerth and Marco Foiani and Saverio Minucci",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

doi = "10.1016/j.ccell.2019.03.007",

language = "English",

volume = "35",

pages = "798--815.e5",

journal = "Cancer Cell",

issn = "1535-6108",

number = "5",

}

Elgendy, M, Cirò, M, Hosseini, A, Weiszmann, J, Mazzarella, L, Ferrari, E, Cazzoli, R, Curigliano, G, DeCensi, A, Bonanni, B, Budillon, A, Pelicci, PG, Janssens, V, Ogris, M , Baccarini, M, Lanfrancone, L, Weckwerth, W, Foiani, M & Minucci, S 2019, 'Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis', Cancer Cell, vol. 35, no. 5, pp. 798-815.e5. https://doi.org/10.1016/j.ccell.2019.03.007

TY - JOUR

T1 - Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

AU - Elgendy, Mohamed

AU - Cirò, Marco

AU - Hosseini, Amir

AU - Weiszmann, Jakob

AU - Mazzarella, Luca

AU - Ferrari, Elisa

AU - Cazzoli, Riccardo

AU - Curigliano, Giuseppe

AU - DeCensi, Andrea

AU - Bonanni, Bernardo

AU - Budillon, Alfredo

AU - Pelicci, Pier Giuseppe

AU - Janssens, Veerle

AU - Ogris, Manfred

AU - Baccarini, Manuela

AU - Lanfrancone, Luisa

AU - Weckwerth, Wolfram

AU - Foiani, Marco

AU - Minucci, Saverio

PY - 2019

Y1 - 2019

KW - metformin

KW - glucose

KW - hypoglycemia

KW - fasting

KW - caloric restriction

KW - MCL-1

KW - GSK3ß

KW - PP2A

KW - metabolic plasticity

KW - tumor metabolism

KW - APOPTOSIS

KW - SUPPRESSOR

KW - ACTIVATION

KW - KINASE

KW - BREAST-CANCER PROLIFERATION

KW - RESTRICTION

KW - RESISTANCE

KW - DEGRADATION

KW - TUMORIGENESIS

KW - MCL1

UR - https://www.scopus.com/pages/publications/85065108746

U2 - 10.1016/j.ccell.2019.03.007

DO - 10.1016/j.ccell.2019.03.007

M3 - Article

C2 - 31031016

SN - 1535-6108

VL - 35

SP - 798-815.e5

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

UN SDGs

Austrian Fields of Science 2012

Keywords

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