Combined Chemisorption and Complexation Generate siRNA Nanocarriers with Biophysics Optimized for Efficient Gene Knockdown and Air-Blood Barrier Crossing

Alexander Taschauer, Wolfram Polzer, Stefan Poeschl, Slavica Metz, Nathalie Tepe, Simon Decker, Norbert Cyran, Julia Scholda, Julia Maier, Hermann Bloss, Martina Anton, Thilo Hofmann, Manfred Ogris (Corresponding author), Haider Sami (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)30095-30111
Number of pages17
JournalACS applied materials & interfaces
Volume12
Issue number27
DOIs
Publication statusPublished - 9 Jun 2020

Austrian Fields of Science 2012

  • 105906 Environmental geosciences
  • 106022 Microbiology

Keywords

  • gold nanoparticle
  • linear polyethylenimine
  • siRNA knockdown
  • pulmonary delivery
  • intratracheal
  • tomograpluc optical imaging
  • biodistribution
  • BY-LAYER NANOPARTICLES
  • GOLD NANOPARTICLES
  • INTRACELLULAR TRAFFICKING
  • SYSTEMIC DELIVERY
  • CELLULAR UPTAKE
  • CLINICAL-TRIAL
  • POLYETHYLENIMINE
  • POLYPLEXES
  • DNA
  • OLIGONUCLEOTIDE
  • tomographic optical imaging

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