Comparative RNA Genomics

Rolf Backofen; Jan Gorodkin; Ivo Hofacker; Peter Stadler

doi:10.1007/978-1-0716-3838-5_12

Comparative RNA Genomics

Rolf Backofen
, Jan Gorodkin
, Ivo Hofacker
, Peter Stadler (Corresponding author)

Publications: Contribution to book › Chapter › Peer Reviewed

Abstract

Over the last quarter of a century it has become clear that RNA is much more than just a boring intermediate in protein expression. Ancient RNAs still appear in the core information metabolism and comprise a surprisingly large component in bacterial gene regulation. A common theme with these types of mostly small RNAs is their reliance of conserved secondary structures. Large-scale sequencing projects, on the other hand, have profoundly changed our understanding of eukaryotic genomes. Pervasively transcribed, they give rise to a plethora of large and evolutionarily extremely flexible non-coding RNAs that exert a vastly diverse array of molecule functions. In this chapter we provide a—necessarily incomplete—overview of the current state of comparative analysis of non-coding RNAs, emphasizing computational approaches as a means to gain a global picture of the modern RNA world.

Original language	English
Title of host publication	Comparative Genomics
Subtitle of host publication	Methods and Protocols
Publisher	Humana, New York, NY
Pages	347–393
Number of pages	47
Edition	2
ISBN (Electronic)	978-1-0716-3838-5
ISBN (Print)	978-1-0716-3837-8, 978-1-0716-3840-8
DOIs	https://doi.org/10.1007/978-1-0716-3838-5_12
Publication status	Published - 1 Jun 2024

Publication series

Series	Methods in Molecular Biology
Volume	2802
ISSN	1064-3745

Funding

This work was funded in part by the German Federal Ministry of Education and Research (BMBF; 031A538B) within the German Network for Bioinformatics Infrastructure (de.NBI), the Deutsche Forschungsgemeinschaft (DFG; qSTA 850/19) within the Priority Programme SPP 1738, the Innovation Fund Denmark (0603- 00320B, 5163-00010B), the Danish Council for Independent Research (DFF-4005-00443).

Austrian Fields of Science 2012

106005 Bioinformatics

Keywords

Alternative splicing
Chromatin
RNA secondary structure
Evolution
long non-coding RNA

Access to Document

10.1007/978-1-0716-3838-5_12

Cite this

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KW - RNA secondary structure

KW - Evolution

KW - long non-coding RNA

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Comparative RNA Genomics

Abstract

Publication series

Funding

Austrian Fields of Science 2012

Keywords

Access to Document

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