Coupling of the engineered DNA "mutator" to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces

Olga N. Sekurova; Yi-Qian Sun; Martin Zehl; Christian Rueckert; Anna Stich; Tobias Busche; Joern Kalinowski; Sergey B. Zotchev

doi:10.1093/nar/gkab583

Coupling of the engineered DNA "mutator" to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces

Olga N. Sekurova
, Yi-Qian Sun
, Martin Zehl
, Christian Rueckert
, Anna Stich
, Tobias Busche
, Joern Kalinowski
, Sergey B. Zotchev (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	8396-8405
Number of pages	10
Journal	Nucleic Acids Research
Volume	49
Issue number	14
Early online date	1 Jul 2021
DOIs	https://doi.org/10.1093/nar/gkab583
Publication status	Published - 20 Aug 2021

Funding

European Commission under the 7th Framework Program through the `Collaborative Project' action `STREPSYNTH' [613877]; University of Vienna; Austrian Science Fund (FWF) [P 30986-B32]. Funding for open access charge: Universit at Wien.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

106002 Biochemistry
106023 Molecular biology
301207 Pharmaceutical chemistry
301204 Pharmacognosy

Keywords

ESCHERICHIA-COLI
POLYMERASE-III
NATURAL-PRODUCTS
GENOME SEQUENCE
EPSILON-SUBUNIT
REPLICATION
MUTATIONS
GENERATION
EXPRESSION
DISCOVERY

Access to Document

10.1093/nar/gkab583Licence: CC BY-NC 4.0

https://phaidra.univie.ac.at/o:1538965Licence: CC BY-NC 4.0

Cite this

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T1 - Coupling of the engineered DNA "mutator" to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces

AU - Sekurova, Olga N.

AU - Sun, Yi-Qian

AU - Zehl, Martin

AU - Rueckert, Christian

AU - Stich, Anna

AU - Busche, Tobias

AU - Kalinowski, Joern

AU - Zotchev, Sergey B.

PY - 2021/8/20

Y1 - 2021/8/20

KW - ESCHERICHIA-COLI

KW - POLYMERASE-III

KW - NATURAL-PRODUCTS

KW - GENOME SEQUENCE

KW - EPSILON-SUBUNIT

KW - REPLICATION

KW - MUTATIONS

KW - GENERATION

KW - EXPRESSION

KW - DISCOVERY

UR - https://www.scopus.com/pages/publications/85114318947

U2 - 10.1093/nar/gkab583

DO - 10.1093/nar/gkab583

M3 - Article

C2 - 34197612

SN - 0305-1048

VL - 49

SP - 8396

EP - 8405

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 14

ER -

Coupling of the engineered DNA "mutator" to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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