Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site

Jiri Wald, Marion Pasin, Martina Richter, Christin Walther, Neann Mathai, Johannes Kirchmair, Vadim A Makarov, Nikolaus Goessweiner-Mohr, Thomas C Marlovits, Irene Zanella, Antonio Real-Hohn, Nuria Verdaguer, Dieter Blaas, Michaela Schmidtke

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Pages (from-to)19109-19115
    Number of pages7
    JournalProceedings of the National Academy of Sciences of the United States of America (PNAS)
    Volume116
    Issue number38
    DOIs
    Publication statusPublished - 17 Sept 2019

    Austrian Fields of Science 2012

    • 106005 Bioinformatics
    • 301207 Pharmaceutical chemistry

    Keywords

    • Antiviral Agents/metabolism
    • Binding Sites
    • Capsid/drug effects
    • Cryoelectron Microscopy/methods
    • Drug Resistance, Viral
    • HeLa Cells
    • Humans
    • Models, Molecular
    • Molecular Structure
    • Oxadiazoles/pharmacology
    • Oxazoles
    • Picornaviridae Infections/drug therapy
    • Protein Binding
    • Protein Conformation
    • Rhinovirus/drug effects
    • Structure-Activity Relationship
    • Viral Proteins/chemistry
    • BROAD-SPECTRUM
    • VIRUS
    • capsid binder
    • SUSCEPTIBILITY
    • RECEPTOR
    • COXSACKIEVIRUS B3
    • REPLICATION
    • inhibitor
    • cryo-EM
    • IN-VITRO ACTIVITY
    • 3D structure
    • COMMON COLDS
    • rhinovirus
    • CONFORMATIONAL-CHANGE
    • INHIBITORS
    • Capsid binder
    • Rhinovirus
    • Cryo-EM
    • Inhibitor

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