Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment

Alexia Tialiou; Jia Min Chin; Bernhard K. Keppler; Michael R. Reithofer

doi:10.3390/biomedicines10061417

Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment

Alexia Tialiou, Jia Min Chin (Corresponding author), Bernhard K. Keppler, Michael R. Reithofer (Corresponding author)

Publications: Contribution to journal › Review › Peer Reviewed

Abstract

Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.

Original language	English
Article number	1417
Number of pages	26
Journal	Biomedicines
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/biomedicines10061417
Publication status	Published - Jun 2022

Austrian Fields of Science 2012

301904 Cancer research
106002 Biochemistry
106023 Molecular biology

Keywords

cancer
gold complexes
N-heterocyclic carbenes
NHC
DNA
G-quadruplex
G-QUADRUPLEX
GOLD(III) COMPLEXES
HISTORY LANDMARKS
METAL-COMPLEXES
GOLD COMPOUNDS
CHEMISTRY
LIGANDS
BINDING

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biomedicines10061417Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1670390Licence: CC BY 4.0

Cite this

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title = "Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment",

abstract = "Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.",

keywords = "cancer, gold complexes, N-heterocyclic carbenes, NHC, DNA, G-quadruplex, G-QUADRUPLEX, GOLD(III) COMPLEXES, HISTORY LANDMARKS, METAL-COMPLEXES, GOLD COMPOUNDS, CHEMISTRY, LIGANDS, BINDING",

author = "Alexia Tialiou and Chin, {Jia Min} and Keppler, {Bernhard K.} and Reithofer, {Michael R.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

doi = "10.3390/biomedicines10061417",

language = "English",

volume = "10",

journal = "Biomedicines",

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AU - Tialiou, Alexia

AU - Chin, Jia Min

AU - Keppler, Bernhard K.

AU - Reithofer, Michael R.

PY - 2022/6

Y1 - 2022/6

N2 - Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.

AB - Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.

KW - cancer

KW - gold complexes

KW - N-heterocyclic carbenes

KW - NHC

KW - DNA

KW - G-quadruplex

KW - G-QUADRUPLEX

KW - GOLD(III) COMPLEXES

KW - HISTORY LANDMARKS

KW - METAL-COMPLEXES

KW - GOLD COMPOUNDS

KW - CHEMISTRY

KW - LIGANDS

KW - BINDING

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U2 - 10.3390/biomedicines10061417

DO - 10.3390/biomedicines10061417

M3 - Review

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JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 6

M1 - 1417

ER -

Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment

Abstract

Austrian Fields of Science 2012

Keywords

UN SDGs

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