TY - JOUR
T1 - Cyclooxygenase-1 and cyclooxygenase-2 inhibition of novel 1,2-disubtituted imidazoles
AU - Handler, Norbert
AU - Jäger, Walter
AU - Kuen-Krismer, Beatrix
AU - Erker, Thomas
N1 - DOI: 10.1002/ardp.200500178
Coden: ARPMA
Affiliations: Department of Medicinal Chemistry, University of Vienna, Vienna, Austria; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria; FH-Campus Vienna, Vienna, Austria; University of Vienna, Department of Medicinal/Pharmaceutical Chemistry, Althanstrasse 14, A-1090 Vienna, Austria
Source-File: MedPharmChemScopus_iso.csv
Import aus Scopus: 2-s2.0-29244457530
Importdatum: 22.11.2006 17:15:52
09.08.2007: Datenanforderung 1815 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2005
Y1 - 2005
N2 - Novel 1,2-disubstituted imidazoles were synthesized and tested for COX-1 and COX-2 inhibition. A substituted phenyl cycle in position 1 and an alicyclic tertiary alcohol in position 2 gave COX-1-selective compounds with potency and selectivity depending on the different substituents. Π2005 Wiley-VCH Verlag GmbH & Co. KGaA.
AB - Novel 1,2-disubstituted imidazoles were synthesized and tested for COX-1 and COX-2 inhibition. A substituted phenyl cycle in position 1 and an alicyclic tertiary alcohol in position 2 gave COX-1-selective compounds with potency and selectivity depending on the different substituents. Π2005 Wiley-VCH Verlag GmbH & Co. KGaA.
U2 - 10.1002/ardp.200500178
DO - 10.1002/ardp.200500178
M3 - Article
SN - 0365-6233
VL - 338
SP - 602
EP - 604
JO - Archiv der Pharmazie
JF - Archiv der Pharmazie
IS - 12
ER -