@article{d7a9d0c0b57e474fad09fbf42d74d0e4,
title = "Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells",
abstract = "Various amphiphilic heterodinucleoside phosphates have recently been synthesized in order to overcome drug resistance. These agents contain 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C). We now investigated the action of two of these novel dimers (# 2 and # 10) in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. The dimers were compared with 5-FdUrd and Ara-C for growth inhibition, apoptosis induction, and cell-cycle effects. No significant difference in the cytotoxicity of dimer # 2 could be observed between sensitive and 5-FdUrd/Ara-C cross-resistant H9 cells (IC50 values of 220 nM and 200 nM, respectively), indicating that further studies with this compound are warranted. {\OE} 2005 Elsevier Ltd. All rights reserved.",
author = "Philipp Saiko and Zsuzsanna Horvath and Christoph Illmer and Wolfgang Bauer and Thomas Hoechtl and Natascha Erlach and Michael Grusch and Georg Krupitza and Robert Mader and Walter J{\"a}ger and Herbert Schott and Agarwal, {Ram P.} and Thomas Szekeres",
note = " DOI: 10.1016/j.leukres.2004.12.015 Coden: LERED Affiliations: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Center of Excellence in Clinical and Experimental Oncology (CLEXO), Medical University of Vienna, Austria; Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria; Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Department of Pharmaceutical Chemistry, Faculty of Natural Sciences and Mathematics, University of Vienna, Althanstra{\ss}e 14, A-1090 Vienna, Austria; Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Tuebingen, Auf der Morgenstelle 18, 72076 Tuebingen, Germany; Department of Medicine, Division of Hematology/Oncology, University of Miami, 1600 N.W. 10th Avenue, Miami, FL 33136, United States Source-File: MedPharmChemScopus_iso.csv Import aus Scopus: 2-s2.0-20344381786 Importdatum: 22.11.2006 17:16:17 09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)",
year = "2005",
language = "English",
volume = "29",
pages = "785--791",
journal = "Leukemia Research",
issn = "0145-2126",
number = "7",
}