Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

Giorgia Del Favero; Alois Bonifacio; Teisha J. Rowland; Shanshan Gao; Kunhua Song; Valter Sergo; Eric D. Adler; Luisa Mestroni; Orfeo Sbaizero; Matthew R. G. Taylor

doi:10.3390/jcm9082457

Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

Giorgia Del Favero (Corresponding author), Alois Bonifacio, Teisha J. Rowland, Shanshan Gao, Kunhua Song, Valter Sergo, Eric D. Adler, Luisa Mestroni, Orfeo Sbaizero, Matthew R. G. Taylor (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	2457
Pages (from-to)	1-20
Number of pages	20
Journal	Journal of clinical medicine
Volume	9
Issue number	8
DOIs	https://doi.org/10.3390/jcm9082457
Publication status	Published - Aug 2020

Austrian Fields of Science 2012

301305 Medical chemistry

Keywords

Danon disease
LAMP-2 deficiency
cardiac fibrosis
multi-omics profiling
mitochondrial aging phenotype
cell biomechanics
HUMAN FIBROBLASTS
CARDIOMYOPATHY
HOMEOSTASIS
EXPRESSION
AUTOPHAGY
FEATURES
PATHWAY
OPOSSUM
DAMAGE
TOOLS
Mitochondrial aging phenotype
Multi-omics profiling
Cardiac fibrosis
Cell biomechanics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jcm9082457Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1184215Licence: CC BY 4.0

Cite this

Del Favero, G., Bonifacio, A., Rowland, T. J., Gao, S., Song, K., Sergo, V., Adler, E. D., Mestroni, L., Sbaizero, O., & Taylor, M. R. G. (2020). Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes. Journal of clinical medicine, 9(8), 1-20. Article 2457. https://doi.org/10.3390/jcm9082457

@article{af457f1d982e42be925ba8028856fa7e,

title = "Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes",

keywords = "Danon disease, LAMP-2 deficiency, cardiac fibrosis, multi-omics profiling, mitochondrial aging phenotype, cell biomechanics, HUMAN FIBROBLASTS, CARDIOMYOPATHY, HOMEOSTASIS, EXPRESSION, AUTOPHAGY, FEATURES, PATHWAY, OPOSSUM, DAMAGE, TOOLS, Mitochondrial aging phenotype, Multi-omics profiling, Cardiac fibrosis, Cell biomechanics",

author = "{Del Favero}, Giorgia and Alois Bonifacio and Rowland, {Teisha J.} and Shanshan Gao and Kunhua Song and Valter Sergo and Adler, {Eric D.} and Luisa Mestroni and Orfeo Sbaizero and Taylor, {Matthew R. G.}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = aug,

doi = "10.3390/jcm9082457",

language = "English",

volume = "9",

pages = "1--20",

journal = "Journal of clinical medicine",

publisher = "MDPI AG",

number = "8",

}

Del Favero, G, Bonifacio, A, Rowland, TJ, Gao, S, Song, K, Sergo, V, Adler, ED, Mestroni, L, Sbaizero, O & Taylor, MRG 2020, 'Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes', Journal of clinical medicine, vol. 9, no. 8, 2457, pp. 1-20. https://doi.org/10.3390/jcm9082457

Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes. / Del Favero, Giorgia (Corresponding author); Bonifacio, Alois; Rowland, Teisha J. et al.
In: Journal of clinical medicine, Vol. 9, No. 8, 2457, 08.2020, p. 1-20.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

AU - Del Favero, Giorgia

AU - Bonifacio, Alois

AU - Rowland, Teisha J.

AU - Gao, Shanshan

AU - Song, Kunhua

AU - Sergo, Valter

AU - Adler, Eric D.

AU - Mestroni, Luisa

AU - Sbaizero, Orfeo

AU - Taylor, Matthew R. G.

PY - 2020/8

Y1 - 2020/8

KW - Danon disease

KW - LAMP-2 deficiency

KW - cardiac fibrosis

KW - multi-omics profiling

KW - mitochondrial aging phenotype

KW - cell biomechanics

KW - HUMAN FIBROBLASTS

KW - CARDIOMYOPATHY

KW - HOMEOSTASIS

KW - EXPRESSION

KW - AUTOPHAGY

KW - FEATURES

KW - PATHWAY

KW - OPOSSUM

KW - DAMAGE

KW - TOOLS

KW - Mitochondrial aging phenotype

KW - Multi-omics profiling

KW - Cardiac fibrosis

KW - Cell biomechanics

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U2 - 10.3390/jcm9082457

DO - 10.3390/jcm9082457

M3 - Article

VL - 9

SP - 1

EP - 20

JO - Journal of clinical medicine

JF - Journal of clinical medicine

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M1 - 2457

ER -

Danon Disease-Associated LAMP-2 Deficiency Drives Metabolic Signature Indicative of Mitochondrial Aging and Fibrosis in Cardiac Tissue and hiPSC-Derived Cardiomyocytes

Austrian Fields of Science 2012

Keywords

UN SDGs

Access to Document

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