Abstract
Ureas stand out as potent pharmacophores in drug development, rendering them a prime focus for synthesis. Herein, we present an appealing entry point for urea synthesis from protected amines (Nms-amides) and relying on a Lossen-type rearrangement process as an elegant example of deprotective functionalisation. The method developed exhibits an exceptionally broad tolerance towards various protected amines, encompassing numerous drug derivatives, and delivers high reaction yields.
Original language | English |
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Pages (from-to) | 15799-15803 |
Number of pages | 5 |
Journal | Chemical Science |
Volume | 15 |
Issue number | 38 |
Early online date | 10 Sep 2024 |
DOIs | |
Publication status | Published - 10 Sep 2024 |
Austrian Fields of Science 2012
- 104015 Organic chemistry