Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA                         A                         ) Receptor Modulators

Marco Stadler; Serena Monticelli; Thomas Seidel; Denise Luger; Isabella Salzer; Stefan Boehm; Wolfgang Holzer; Christoph Schwarzer; Ernst Urban; Sophia Khom; Thierry Langer; Vittorio Pace; Steffen Hering

doi:10.1021/acs.jmedchem.8b00859

Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA _A ) Receptor Modulators

Marco Stadler, Serena Monticelli, Thomas Seidel, Denise Luger, Isabella Salzer, Stefan Boehm, Wolfgang Holzer, Christoph Schwarzer, Ernst Urban, Sophia Khom, Thierry Langer, Vittorio Pace, Steffen Hering

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	317-341
Number of pages	25
Journal	Journal of Medicinal Chemistry
Volume	62
Issue number	1
DOIs	https://doi.org/10.1021/acs.jmedchem.8b00859
Publication status	Published - 1 Oct 2019

Funding

Financial support to S.H. was provided by the Austrian Science Fund (FWF). M.S. is a fellow of the FWF-funded doctoral program “Molecular Drug Targets” W1232. T.L., S.B., and S.H. receive support from the interuniversity cluster project “Novel scaffolds for improved antiepileptic drugs” financed by the University of Vienna and the Medical University of Vienna. We thank Dr. Marcel van der Heyden for critical reading of the manuscript.

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry
301206 Pharmacology

Keywords

BENZODIAZEPINE BINDING-SITE
VALERENIC ACID
3D PHARMACOPHORE
INTERNATIONAL UNION
EFFICIENT SYNTHESIS
LIGAND RECOGNITION
NATURAL-PRODUCTS
SUBTYPES
ANTICONVULSANT
CHANNELS

Access to Document

10.1021/acs.jmedchem.8b00859

Cite this

Stadler, M., Monticelli, S., Seidel, T., Luger, D., Salzer, I., Boehm, S., Holzer, W., Schwarzer, C., Urban, E., Khom, S., Langer, T., Pace, V., & Hering, S. (2019). Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA _A ) Receptor Modulators. Journal of Medicinal Chemistry, 62(1), 317-341. https://doi.org/10.1021/acs.jmedchem.8b00859

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author = "Marco Stadler and Serena Monticelli and Thomas Seidel and Denise Luger and Isabella Salzer and Stefan Boehm and Wolfgang Holzer and Christoph Schwarzer and Ernst Urban and Sophia Khom and Thierry Langer and Vittorio Pace and Steffen Hering",

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Stadler, M, Monticelli, S, Seidel, T, Luger, D, Salzer, I, Boehm, S, Holzer, W, Schwarzer, C, Urban, E , Khom, S , Langer, T, Pace, V & Hering, S 2019, 'Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA _A ) Receptor Modulators', Journal of Medicinal Chemistry, vol. 62, no. 1, pp. 317-341. https://doi.org/10.1021/acs.jmedchem.8b00859

Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA _A ) Receptor Modulators. / Stadler, Marco; Monticelli, Serena; Seidel, Thomas et al.
In: Journal of Medicinal Chemistry, Vol. 62, No. 1, 01.10.2019, p. 317-341.

Publications: Contribution to journal › Article › Peer Reviewed

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AU - Luger, Denise

AU - Salzer, Isabella

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AU - Schwarzer, Christoph

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