Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib

Bjoern Bielec; Hemma Schueffl; Alessio Terenzi; Walter Berger; Petra Heffeter; Bernhard K. Keppler; Christian R. Kowol

doi:10.1016/j.bioorg.2020.103778

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib

Bjoern Bielec
, Hemma Schueffl
, Alessio Terenzi
, Walter Berger
, Petra Heffeter (Corresponding author)
, Bernhard K. Keppler
, Christian R. Kowol (Corresponding author)

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	103778
Number of pages	10
Journal	Bioorganic Chemistry
Volume	99
DOIs	https://doi.org/10.1016/j.bioorg.2020.103778
Publication status	Published - Jun 2020

Funding

This work was financially supported by the Austrian Science Fund (FWF) [grant number P28853, to C.R.K.]. We thank Ing. Alexander Roller and Natalie Lukic for X-ray crystallographic measurements.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

104015 Organic chemistry
301904 Cancer research
106002 Biochemistry
106023 Molecular biology

Keywords

Tyrosine kinase inhibitor
Prodrugs
Hypoxia
Crizotinib
Nitroimidazole
CELL LUNG-CANCER
ACQUIRED-RESISTANCE
DESIGN
GROWTH
MODELS
EGFR

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10.1016/j.bioorg.2020.103778

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@article{c49eeb924b104002aac8a0296efef532,

title = "Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib",

keywords = "Tyrosine kinase inhibitor, Prodrugs, Hypoxia, Crizotinib, Nitroimidazole, CELL LUNG-CANCER, ACQUIRED-RESISTANCE, DESIGN, GROWTH, MODELS, EGFR",

author = "Bjoern Bielec and Hemma Schueffl and Alessio Terenzi and Walter Berger and Petra Heffeter and Keppler, \{Bernhard K.\} and Kowol, \{Christian R.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

doi = "10.1016/j.bioorg.2020.103778",

language = "English",

volume = "99",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Elsevier",

}

TY - JOUR

T1 - Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib

AU - Bielec, Bjoern

AU - Schueffl, Hemma

AU - Terenzi, Alessio

AU - Berger, Walter

AU - Heffeter, Petra

AU - Keppler, Bernhard K.

AU - Kowol, Christian R.

PY - 2020/6

Y1 - 2020/6

KW - Tyrosine kinase inhibitor

KW - Prodrugs

KW - Hypoxia

KW - Crizotinib

KW - Nitroimidazole

KW - CELL LUNG-CANCER

KW - ACQUIRED-RESISTANCE

KW - DESIGN

KW - GROWTH

KW - MODELS

KW - EGFR

UR - https://www.scopus.com/pages/publications/85082482736

U2 - 10.1016/j.bioorg.2020.103778

DO - 10.1016/j.bioorg.2020.103778

M3 - Article

SN - 0045-2068

VL - 99

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 103778

ER -

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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