Development of new Kir2.1 channel openers from propafenone analogues

Encan Li; Najla Boujeddaine; Marien J.C. Houtman; Renee G.C. Maas; Joost P.G. Sluijter; Gerhard F. Ecker; Anna Stary-Weinzinger; Willem B. van Ham; Marcel A.G. van der Heyden

doi:10.1111/bph.17377

Development of new Kir2.1 channel openers from propafenone analogues

Encan Li
, Najla Boujeddaine
, Marien J.C. Houtman
, Renee G.C. Maas
, Joost P.G. Sluijter
, Gerhard F. Ecker
, Anna Stary-Weinzinger
, Willem B. van Ham
, Marcel A.G. van der Heyden (Corresponding author)

Department of Pharmaceutical Sciences

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	633-650
Number of pages	18
Journal	British Journal of Pharmacology
Volume	182
Issue number	3
DOIs	https://doi.org/10.1111/bph.17377
Publication status	Published - 17 Oct 2024

Funding

We did not preregister this research with an analysis plan in an independent institutional registry. E. Li received financial support from the China Scholarship Council. Funding for the present work was provided by TOP\u2010EVICARE (101138069) of the European Research Council (ERC), Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) TTP HARVEY (2021/TTW/01038252), ZonMW PSIDER (10250022110004), NWO\u2010Take\u2010off 1 VINCI (2023/TTW/01494519) and Health Holland EV\u2010Protect (TKI2306). We thank S. Bendahhou (Universit\u00E9 C\u00F4te d'Azur, Nice, France) for providing Andersen\u2013Tawil Syndrome mutant expression constructs.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

cardiac pharmacology
drug discovery/target validation
hiPSC-CMCs
ion channels
K2.1 channel
off-target effects
propafenone analogues

Access to Document

10.1111/bph.17377

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17377

Cite this

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title = "Development of new Kir2.1 channel openers from propafenone analogues",

keywords = "cardiac pharmacology, drug discovery/target validation, hiPSC-CMCs, ion channels, K2.1 channel, off-target effects, propafenone analogues",

author = "Encan Li and Najla Boujeddaine and Houtman, \{Marien J.C.\} and Maas, \{Renee G.C.\} and Sluijter, \{Joost P.G.\} and Ecker, \{Gerhard F.\} and Anna Stary-Weinzinger and \{van Ham\}, \{Willem B.\} and \{van der Heyden\}, \{Marcel A.G.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). British Journal of Pharmacology published by John Wiley \& Sons Ltd on behalf of British Pharmacological Society.",

year = "2024",

month = oct,

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doi = "10.1111/bph.17377",

language = "English",

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AU - Li, Encan

AU - Boujeddaine, Najla

AU - Houtman, Marien J.C.

AU - Maas, Renee G.C.

AU - Sluijter, Joost P.G.

AU - Ecker, Gerhard F.

AU - Stary-Weinzinger, Anna

AU - van Ham, Willem B.

AU - van der Heyden, Marcel A.G.

PY - 2024/10/17

Y1 - 2024/10/17

KW - cardiac pharmacology

KW - drug discovery/target validation

KW - hiPSC-CMCs

KW - ion channels

KW - K2.1 channel

KW - off-target effects

KW - propafenone analogues

UR - https://www.scopus.com/pages/publications/85206801031

U2 - 10.1111/bph.17377

DO - 10.1111/bph.17377

M3 - Article

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SP - 633

EP - 650

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 3

ER -

Development of new Kir2.1 channel openers from propafenone analogues

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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Cite this