TY - JOUR
T1 - Diagnostic Performance of Urinary Resveratrol Metabolites as a Biomarker of Moderate Wine Consumption
AU - Zamora-Ros, Raul
AU - Urpi-Sarda, Mireia
AU - Lamuela-Raventos, Rosa M.
AU - Estruch, Ramón
AU - Vazquez-Agell, Mónica
AU - Serrano-Martinez, Manuel
AU - Jäger, Walter
AU - Andres-Lacueva, Cristina
N1 - DOI: 10.1373/clinchem.2005.065870
Coden: CLCHA
Affiliations: Nutrition and Food Science Department-CeRTA, Pharmacy School, University of Barcelona, Barcelona, Spain; Department of Internal Medicine, Institut d'Investigacio¿ Biome`dica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria; Nutrition and Food Sciences Department-CeRTA, Pharmacy School, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain
Source-File: MedPharmChemScopus_iso.csv
Import aus Scopus: 2-s2.0-33745471738
Importdatum: 22.11.2006 17:16:30
PY - 2006
Y1 - 2006
N2 - Background: Nutritional biomarkers may be better measures of dietary exposure than self-reported dietary data. We evaluated resveratrol metabolites, potential biomarkers of wine consumption, in humans after moderate consumption of sparkling, white, or red wines. Methods: We performed 2 randomized, crossover trials and a cohort study. In the first study, 10 healthy men consumed 30 g of ethanol/day as sparkling wine or gin for 28 days. In the second trial, 10 healthy women consumed 20 g of ethanol/day as white or red wine for 28 days. We also evaluated 52 participants in a study on the effects of a Mediterranean diet on primary prevention of cardiovascular disease (the PREDIMED Study). We used liquid chromatography-tandem mass spectrometry to analyze urinary total resveratrol metabolites (TRMs) and predictive values and ROC curve analyses to assess the diagnostic accuracy. Results: We observed significant increases in TRMs [72.4 (95% confidence interval, 48.5-96.2; P = 0.005), 211.5 (166.6-256.3; P = 0.005), and 560.5 nmol/g creatinine (244.9-876.1; P = 0.005)] after consumption of sparkling, white, or red wine, respectively, but no changes after the washout or gin periods. In the cohort study, the reported daily dose of wine consumption correlated directly with TRMs (r = 0.654; P
AB - Background: Nutritional biomarkers may be better measures of dietary exposure than self-reported dietary data. We evaluated resveratrol metabolites, potential biomarkers of wine consumption, in humans after moderate consumption of sparkling, white, or red wines. Methods: We performed 2 randomized, crossover trials and a cohort study. In the first study, 10 healthy men consumed 30 g of ethanol/day as sparkling wine or gin for 28 days. In the second trial, 10 healthy women consumed 20 g of ethanol/day as white or red wine for 28 days. We also evaluated 52 participants in a study on the effects of a Mediterranean diet on primary prevention of cardiovascular disease (the PREDIMED Study). We used liquid chromatography-tandem mass spectrometry to analyze urinary total resveratrol metabolites (TRMs) and predictive values and ROC curve analyses to assess the diagnostic accuracy. Results: We observed significant increases in TRMs [72.4 (95% confidence interval, 48.5-96.2; P = 0.005), 211.5 (166.6-256.3; P = 0.005), and 560.5 nmol/g creatinine (244.9-876.1; P = 0.005)] after consumption of sparkling, white, or red wine, respectively, but no changes after the washout or gin periods. In the cohort study, the reported daily dose of wine consumption correlated directly with TRMs (r = 0.654; P
M3 - Article
SN - 0009-9147
VL - 52
SP - 1373
EP - 1380
JO - Clinical Chemistry: international journal of molecular diagnostics and laboratory medicine
JF - Clinical Chemistry: international journal of molecular diagnostics and laboratory medicine
IS - 7
ER -
