Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

Wenjie Xue; Yaling Wang; Xu Lian; Xueyao Li; Jing Pang; Johannes Kirchmair; Kebin Wu; Zunsheng Han; Xuefu You; Hongmin Zhang; Jie Xia; Song Wu

doi:10.1080/14756366.2022.2084088

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

Wenjie Xue, Yaling Wang, Xu Lian, Xueyao Li, Jing Pang, Johannes Kirchmair, Kebin Wu, Zunsheng Han, Xuefu You, Hongmin Zhang, Jie Xia, Song Wu

Department of Pharmaceutical Sciences

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	1620-1631
Number of pages	12
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	37
Issue number	1
DOIs	https://doi.org/10.1080/14756366.2022.2084088
Publication status	Published - 31 Dec 2022

Funding

This work was supported by the CAMS Innovation Fund for Medical Sciences [Grant No. 2021-I2M-1-069], Fundamental Research Program of Shanxi Province [Grant No. 20210302124300], the Shanxi Bethune Hospital Scientific Research Fund for Talent Recruitment [Grant No. 2021RC008], "Universities and Colleges Key Programs for Foreign Talent" of State Administration of Foreign Experts Affairs P.R. China [Grant No. T2018042].

Austrian Fields of Science 2012

106005 Bioinformatics
301207 Pharmaceutical chemistry

Keywords

Antibiotic resistance
MRSA
antibacterial agent
DNA Gyrase inhibitors
computer-aided drug design
ATPASE INHIBITORS
TOPOISOMERASE

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10.1080/14756366.2022.2084088Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1669053Licence: CC BY 4.0

Cite this

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title = "Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents",

keywords = "Antibiotic resistance, MRSA, antibacterial agent, DNA Gyrase inhibitors, computer-aided drug design, ATPASE INHIBITORS, TOPOISOMERASE",

author = "Wenjie Xue and Yaling Wang and Xu Lian and Xueyao Li and Jing Pang and Johannes Kirchmair and Kebin Wu and Zunsheng Han and Xuefu You and Hongmin Zhang and Jie Xia and Song Wu",

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T1 - Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

AU - Xue, Wenjie

AU - Wang, Yaling

AU - Lian, Xu

AU - Li, Xueyao

AU - Pang, Jing

AU - Kirchmair, Johannes

AU - Wu, Kebin

AU - Han, Zunsheng

AU - You, Xuefu

AU - Zhang, Hongmin

AU - Xia, Jie

AU - Wu, Song

PY - 2022/12/31

Y1 - 2022/12/31

KW - Antibiotic resistance

KW - MRSA

KW - antibacterial agent

KW - DNA Gyrase inhibitors

KW - computer-aided drug design

KW - ATPASE INHIBITORS

KW - TOPOISOMERASE

UR - https://www.scopus.com/pages/publications/85131362786

U2 - 10.1080/14756366.2022.2084088

DO - 10.1080/14756366.2022.2084088

M3 - Article

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EP - 1631

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

IS - 1

ER -

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

Funding

Austrian Fields of Science 2012

Keywords

Access to Document

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