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Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures

  • Rene Cervenka
  • , Peter Lukacs
  • , Vaibhavkumar S Gawali
  • , Song Ke
  • , Xaver Koenig
  • , Lena Rubi
  • , Touran Zarrabi
  • , Karlheinz Hilber
  • , Walter Sandtner
  • , Anna Stary-Weinzinger
  • , Hannes Todt (Corresponding author)

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Article number631
    Number of pages15
    JournalScientific Reports
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - 12 Jan 2018

    Austrian Fields of Science 2012

    • 301206 Pharmacology

    Keywords

    • Animals
    • Cysteine/genetics
    • Enzyme Activation
    • Models, Molecular
    • Molecular Dynamics Simulation
    • Muscle Proteins/chemistry
    • Mutation
    • Protein Structure, Tertiary
    • Rats
    • Sodium Channels/chemistry
    • Xenopus laevis/genetics
    • IONIC SELECTIVITY
    • MOLECULAR-DYNAMICS
    • ALPHA-SUBUNIT
    • MUSCLE SODIUM-CHANNEL
    • SELECTIVITY FILTER
    • SLOW INACTIVATION
    • AMINO-ACID-RESIDUES
    • SEGMENT IVS6
    • DEPENDENT CONFORMATIONAL-CHANGES
    • MUTATIONS

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