Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF

Ashenafi Damtew Mamuye; Serena Monticelli; Laura Castoldi; Wolfgang Holzer; Vittorio Pace

doi:10.1039/c5gc01002k

Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF

Ashenafi Damtew Mamuye, Serena Monticelli, Laura Castoldi, Wolfgang Holzer, Vittorio Pace

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.

Original language	English
Pages (from-to)	4194-4197
Number of pages	4
Journal	Green Chemistry
Volume	17
Issue number	8
DOIs	https://doi.org/10.1039/c5gc01002k
Publication status	Published - 1 Aug 2015

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

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10.1039/c5gc01002k

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abstract = "A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.",

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AU - Mamuye, Ashenafi Damtew

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AU - Castoldi, Laura

AU - Holzer, Wolfgang

AU - Pace, Vittorio

PY - 2015/8/1

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AB - A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.

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JO - Green Chemistry

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Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF

Abstract

Austrian Fields of Science 2012

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